Macrophage Enzyme ALOXE3 Emerges as a Modulator of Acetaminophen Liver Injury
A multi-omics study identifies macrophage ALOXE3 as a modulator of oxidative stress in acetaminophen-induced liver injury, with overexpression reducing liver ...
Tag: single-cell transcriptomics
Myricetin Targets HSP90AA1 to Curb Bladder Cancer Growth in Preclinical Models
A new multi-omics study reports that myricetin from Myrica rubra binds HSP90AA1, suppresses PI3K–Akt signaling and inhibits bladder cancer growth ...
Six-gene T cell signature predicts survival in hepatocellular carcinoma
A six-gene T cell-derived signature built from single-cell transcriptomics stratified hepatocellular carcinoma patients by survival risk in two independent cohorts.
Variational Autoencoders for Biomedical Data: New Study Maps Their Inner Workings
A new study explains how variational autoencoders integrate multimodal biomedical data and reveals key limitations of in silico perturbation analyses.
Computational Study Points to CYP1B1 as Kaempferol Target in Renal Fibrosis
A computational study combining transcriptomics, machine learning and single-cell analysis identifies CYP1B1 as a potential functional target of kaempferol in ...
Transcriptomics Reveals How Insects Cope With Heat, Pesticides and Pathogens
A systematic review of 166 studies shows how transcriptomics is decoding insect development, stress responses and pest management at the ...
Machine Learning Model Links Tumor Cell Malignancy to Osteosarcoma Outcomes and Flags OPN3 as a Drug Target Candidate
A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...
Immunotherapy plus chemotherapy shows durable responses in lymph-node-dominant metastatic gallbladder cancer
A retrospective Chinese study reports that all 11 patients with lymph-node-dominant metastatic gallbladder cancer responded to PD-1 blockade plus gemcitabine ...
Schwann Cells Rewired by Tumors May Shape Nerve Invasion and Immune Responses
A new review describes how tumors reprogram Schwann cells into states linked to perineural invasion, matrix remodeling and altered immune-cell ...
Viral Tracing Reveals an Asymmetric Visual Circuit in the Bird Brain Built Around SATB2 Neurons
Viral tracing, transcriptomics and electrophysiology in pigeons reveal a strongly asymmetric feedforward circuit between the avian entopallium and mesopallium ventrolaterale ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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