Diabetic Retinopathy Rewritten as a Stage-by-Stage Signaling Map
Diabetic retinopathy has long been treated in clinics as a disease of leaky blood vessels, but a new review argues ...
Tag: signaling
Detoxified aconitine metabolite benzoylaconine stalls colorectal cancer via CDK2/MMP2 axis
Benzoylaconine, a detoxified metabolite of aconitine, arrests colorectal cancer cells at the G1/S transition by directly binding CDK2 and MMP2, ...
Hidden micropeptide KAPEP unshackles JAK-STAT signaling in KRAS-mutant colorectal cancer
Scientists have uncovered a previously hidden layer of the genome that appears to help KRAS-mutant colorectal cancer grow and spread. ...
Copper Transporter CTR1 Acts as Signaling Organizer, Not Just Importer
Copper transporter 1, the membrane protein long celebrated as the body's high-affinity copper gateway, is emerging as something far more ...
Myeloid IL6/STAT3 Signaling Builds Immunosuppressive Niche That Fuels Colitis-Linked Cancer
Multi-omics study reveals how myeloid-derived IL6/JAK/STAT3 signaling creates a spatially organized immunosuppressive niche that drives colitis-associated carcinogenesis, offering a potential ...
Sororin Helps Liver Cancer Evade Ferroptosis Through PP2Ac–p53–STEAP3 Axis
CDCA5, better known as Sororin, shields hepatocellular carcinoma cells from iron-driven cell death by boosting PP2Ac, dampening p53 signaling, and ...
R-spondins suppress adipogenic differentiation in fibro-adipogenic progenitors via autocrine WNT/β-catenin signaling
Deep inside every skeletal muscle, scattered among the fibers that generate force, lives a population of stromal cells with a ...
Mitochondrial Sirt3 loss disrupts fat-burning brake in female fat cells
New research shows that losing the mitochondrial enzyme Sirtuin 3 selectively impairs AMPK–Acc1 antilipogenic signaling in female fat cells, driving ...
Heat Pushes Blood Toward Clotting: Signaling Lipids Flag Early Cardiovascular Risk
A Beijing panel study shows heat exposure raises thrombosis-related signaling lipids by up to 2,484 percent, with lipid changes emerging ...
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
The next revolution in cancer medicine may not come from a new drug molecule but from a family of proteins ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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