Rat Incisors Reveal How Diabetes Drives Inflammatory Cell Death in Teeth
New research links slowed incisor growth in diabetic rats to oxidative stress and RIPK3–MLKL necroptosis signaling within the dental pulp.
Tag: RIPK3
Viral Z-RNA Sensor ZBP1 Emerges as a Switch to Turn Cold Tumors Hot for Immunotherapy
Researchers argue that the innate immune sensor ZBP1, which detects left-handed Z-form nucleic acids and triggers necroptosis, can be pharmacologically ...
Crushed by Crowding: Tumor Pressure Triggers Cancer Cell Self-Destruction, Study Finds
New research shows that sustained mechanical confinement inside densely packed tumors activates necroptosis in migratory cancer cells, halting metastasis and ...
Molecular Tags of Cell Death: How E3 Ubiquitin Ligases Steer Necroptosis in Cancer
A new review explains how E3 ubiquitin ligases attach molecular tags to the necroptosis machinery, shaping both cancer development and ...
Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Cell Death Signature in Gut Lining Predicts Inflammatory Bowel Disease Relapse
A new study shows that a necroptotic-to-apoptotic cell death axis in intestinal epithelial cells, driven by TNF and interferon gamma, ...
Osteocyte Necroptosis Emerges as Hidden Driver of Steroid-Linked Bone Loss
New research shows that inflammatory necroptotic death of osteocytes drives cortical bone destruction in glucocorticoid-induced osteoporosis through osteocytic osteolysis.
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
New necroferrins strategy simultaneously targets necroptosis and ferroptosis
A new review in Ferroptosis and Oxidative Stress examines whether one class of compounds could suppress two interconnected forms of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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