Proteasome inhibitor primes temozolomide response in a molecular subset of recurrent glioblastoma
An interim analysis of the BORTEM-17 phase IB/II trial found that sequential bortezomib and temozolomide achieved disease control in four ...
Tag: Proteomics
Protein maps trace how liver, lung and spleen respond to disseminated Talaromyces marneffei infection
An organ-resolved proteomic study in mice maps shared and organ-specific host responses to disseminated Talaromyces marneffei infection.
Genetic evidence challenges the obesity paradox in cardiovascular-kidney-metabolic disease
A combined epidemiological and genetic analysis finds that genetic susceptibility to higher BMI shows a linear adverse association with mortality, ...
Eight Practical Tips for Navigating the Reactome Pathway Knowledgebase
A new PLOS Computational Biology guide from the Reactome curation team offers eight practical tips for exploring, analyzing and reusing ...
Rheumatism drug teriflunomide shows subtype-dependent effects in breast cancer cells
A cell study finds teriflunomide suppresses growth signalling in luminal breast cancer cells while triple-negative cells show adaptive kinase rewiring.
Exosomes Emerge as Powerful Liquid Biopsy Biomarkers, Review Finds
A new review in Molecular Biology Reports summarizes how exosome-based diagnostics are advancing across oncology, neurology, cardiology and infectious disease, ...
Martian-Level Radiation Leaves Vitamin-Making Microbes Mostly Unfazed
A seven-day gamma irradiation study found that two food-grade microbes kept growth and riboflavin production stable at Mars-mission dose rates, ...
Presarcopenia in older adults flags higher osteoporosis risk in UK Biobank study
A prospective UK Biobank study finds that older adults with presarcopenic phenotypes show a suggestively higher risk of incident osteoporosis, ...
Gut and Blood Metabolites Move Together in Cardiovascular-Kidney-Metabolic Syndrome, Small Study Finds
A cross-sectional study of 44 participants reports exploratory links between serum and fecal metabolites, including a positive correlation in pyrimidine ...
Mass spectrometry workflow fishes receptor-binding toxins straight from snake venom
A new label-free affinity-capture workflow coupled to mass spectrometry recovers known receptor-binding venom toxins and prioritizes new candidates from complex ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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