Tiny Vesicles Reveal How Toxoplasma gondii Quietly Rewires Its Host
A new review argues that extracellular vesicles released by Toxoplasma gondii and infected host cells act as strategic molecular messengers ...
Tag: Proteomics
Proteomics and machine learning expose hidden toxicity in protein degrader drugs
High-throughput proteomics and machine learning revealed that cereblon-recruiting androgen receptor degraders inhibit mitochondrial complex I, and guided linker modifications that ...
BRCA Carriers Show Distinct Protein Signatures in Healthy Breast Tissue, Study Finds
A Mayo Clinic-led proteomic study of nearly 5,000 proteins in nonmalignant breast tissue reveals that cancer-free BRCA1/2 mutation carriers show ...
Million-Peptide Map Reveals Which Malaria Proteins the Immune System Sees
A high-density peptide array covering the entire Plasmodium vivax proteome has identified 283 immunogenic proteins and revealed a distinctive antibody ...
Aging May Stem From a Genome-Wide Shift That Sidelined Cellular Maintenance
A new GeroScience study finds that after sexual maturity, housekeeping genes lose transcriptional share to specialized integrative genes across species, ...
Protein Clues Reveal How Lentils Survive Drought, Salt and Alkaline Soils
The first proteomic study of lentil seedling responses identifies 707 stress-responsive proteins and a shared antioxidant core that separates tolerant ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
Aging Cells Lose Their Recycling Machinery, Letting Senescent Cells Pile Up
New research in Nature Aging shows that the age-related decline of chaperone-mediated autophagy distorts the senescent cell secretome and disables ...
Oyster Parasite Reveals Ancient Blueprint of Divergent Mitochondrial Machinery
Complexome profiling of the oyster parasite Perkinsus marinus shows that the divergent mitochondrial complexes of apicomplexan parasites are an ancient, ...
Protective APOE2 Gene Softens the Damage Wrought by Alzheimer’s Risk Gene APOE4
New research in mice shows that the protective APOE2 allele actively counteracts amyloid plaque buildup, microglial dysfunction, and proteomic changes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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