Buckwheat Compound Fagopyrine Emerges as Computational Lead for AKT1 Cancer Drug Design
A pan-cancer computational study identified the buckwheat-derived compound fagopyrine as a strong predicted binder to the AKT1 kinase, positioning it ...
Tag: PI3K/AKT/mTOR
Tiny Tumors, Big Challenges: New Map of Pituitary Cancer Biology and Drug Delivery
A new review maps the molecular drivers of pituitary neuroendocrine tumors, evaluates established and emerging drug therapies, and separates clinically ...
Zebrafish Reveal a Surprising Trick for Rebuilding Nerves: Letting Dendrites Go First
New research in adult zebrafish shows that transient dendritic pruning driven by repressed mTORC1 signaling is essential for efficient axonal ...
Curcumin Shows Promise Against Ovarian Cancer, but Nanotechnology May Hold the Key
A systematic review of 21 preclinical studies finds that curcumin and its nanoformulations modulate key cancer signaling pathways and enhance ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Early-Life NAD+ Booster Shows Promise for Cognitive Deficits in Schizophrenia Model
A short course of the NAD+ precursor NMN given to young mice in a two-hit schizophrenia model was associated with ...
Cellular Freight Protein YKT6 Emerges as a Driver of Lung Cancer Growth
A new study finds that the vesicle-trafficking SNARE protein YKT6 is overexpressed in lung cancer, where it drives proliferation and ...
Parkinson’s Protein Alpha-Synuclein Drives Clogged Arteries by Jamming Cellular Recycling
New research shows that alpha-synuclein, best known for its role in Parkinson's disease, enters macrophages through the protein FLOT1, blocks ...
Starvation on a Petri Dish: How Fasting Rewires Cancer Cells and Exposes Their Weaknesses
A systematic review of eleven in vitro studies finds that fasting conditions consistently suppress IGF-1 and PI3K/AKT/mTOR signaling, inhibit glycolysis, ...
Scientists Uncover Hidden Feedback Loop That Drives Colon Cancer Spread
A newly mapped SFRP2–Snai1–USP11 feedback loop stabilizes a key metastasis protein and activates PI3K/AKT/mTOR signalling, revealing fresh targets against colon ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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