Tag: PD-1

A phase 2 trial found that the HDAC inhibitor entinostat combined with nivolumab produced no tumor responses in advanced cholangiocarcinoma, ...

A new meta-analysis of nearly 12,000 patients links early-day immune checkpoint inhibitor infusions with markedly better survival in advanced solid ...

Researchers created a mouse model of refractory gastric cancer and discovered that the YAP-driven BST2 protein reprograms neutrophils and Kupffer ...

A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...

A network meta-analysis of eight Phase III trials involving 7,127 patients suggests that the PD-1/CTLA-4 bispecific antibody cadonilimab plus chemotherapy ...

A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...

A review in Experimental & Molecular Medicine examines how chronic antigen exposure and a hostile tumour microenvironment reprogram T cells ...

A Japanese study found that immune-related adverse events during checkpoint inhibitor therapy for advanced gastric cancer were independently linked to ...

A new review shows that physical exercise can remodel the tumor microenvironment to convert immunologically cold tumors into treatment-responsive ones ...

A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...