New Immune Checkpoint Discovery Explains Why Gastric Cancers Ignore PD-1 Drugs
Researchers created a mouse model of refractory gastric cancer and discovered that the YAP-driven BST2 protein reprograms neutrophils and Kupffer ...
Tag: PD-1
PD-1 and LAG-3 Double-Positive T Cells Predict Better Gastric Cancer Survival
A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...
Bispecific Antibody Cadonilimab Shows Survival Edge Over PD-1 Drugs in Gastric Cancer
A network meta-analysis of eight Phase III trials involving 7,127 patients suggests that the PD-1/CTLA-4 bispecific antibody cadonilimab plus chemotherapy ...
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Scientists Map How Tumours Push Immune Cells Into Exhaustion
A review in Experimental & Molecular Medicine examines how chronic antigen exposure and a hostile tumour microenvironment reprogram T cells ...
Immune Side Effects May Signal Stronger Tumor Shrinkage and Longer Survival in Gastric Cancer
A Japanese study found that immune-related adverse events during checkpoint inhibitor therapy for advanced gastric cancer were independently linked to ...
Exercise May Turn Cold Tumors Hot and Boost Immunotherapy Response
A new review shows that physical exercise can remodel the tumor microenvironment to convert immunologically cold tumors into treatment-responsive ones ...
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
Harnessing T-Cell Exhaustion to Improve Organ Transplantation Outcomes
A new review in Genes & Diseases examines how T cell exhaustion may become both an obstacle and an opportunity ...
Revealing the Inverse Relationship of KLRG1 and PD-1 in Tumor Infiltrating CD8 T Cells
In the evolving landscape of cancer treatment, the intricate interaction between immune cells and tumor microenvironments remains a focal point ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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