Mouse study maps how porcine circovirus type 2d reshapes immune cells
A mouse study found that PCV2d infection activated lymphocyte subsets on distinct schedules, triggered thymic T-cell apoptosis, shifted memory T-cell ...
Tag: PD-1
Checkpoint Inhibitors Show Promise for People With HIV, but Africa Remains Excluded
A new review finds checkpoint inhibitors are safe and effective for virologically suppressed people with HIV, while sub-Saharan Africa remains ...
GMP kit enables ready-to-use zirconium-89 pembrolizumab PET imaging agent
Researchers have formulated a GMP-quality kit for preparing a zirconium-89 labelled pembrolizumab PET imaging agent, with preclinical studies supporting safety ...
Leukemia inhibitory factor shifts immune checkpoint gene expression in abortion-prone mice
A mouse study finds that leukemia inhibitory factor alters the expression of several immune checkpoint-related genes in the decidua of ...
Stress and cancer immunotherapy: distress linked to poorer checkpoint inhibitor outcomes
A new review finds that pretreatment psychological distress is consistently associated with poorer outcomes after immune checkpoint inhibitor therapy, while ...
Tumor Protein RNF128 Linked to Immune Resistance in Bladder Cancer
A new study links tumor-cell RNF128 to reduced CD8-positive T-cell infiltration and poorer immune checkpoint blockade responses in bladder cancer.
Iron-Engineered Nanoplatform Delivers DMDD and Targets Immune Checkpoints in Breast Cancer Model
An iron-engineered mesoporous organosilica nanoplatform improved delivery of the natural compound DMDD and inhibited breast tumor growth in preclinical models ...
T cells in AML are not uniformly dysfunctional, researchers argue in new analysis
A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...
Liver Injury Affects One in Eight Patients on Immune Checkpoint Inhibitors in Real-World Study
A retrospective study of 682 patients in Tianjin found 12.17 percent developed liver injury on immune checkpoint inhibitor therapy, with ...
Checkpoint inhibitors improve survival in pMMR metastatic colorectal cancer meta-analysis
A meta-analysis of six randomized trials found that adding PD-1/PD-L1 inhibitors to chemotherapy was associated with longer progression-free and overall ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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