Intravenous STING Agonist Supercharges Radiotherapy to Trigger Anti-Tumour Immunity
A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...
Tag: PD-1
Flow cytometry maps how immune cells remodel across seven decades of life in Chinese adults
A prospective flow cytometry study of 146 healthy Chinese adults aged 20 to 92 reveals coordinated age-related remodeling of T ...
Single-cell map shows how pancreatic cancer clones evolve to outsmart treatment
A single-cell analysis of nearly half a million cells from pancreatic tumors reveals how evolving clones reshape their DNA to ...
Immune Checkpoint Blockers and Engineered Cells Reshape the Fight Against Oral Cavity Cancer
A new review in Molecular Biology Reports maps how checkpoint inhibitors, engineered cell therapies, and emerging immunotherapies are transforming treatment ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
When Cancer Immunotherapy Attacks the Pituitary: Largest Case-Based Analysis Maps Nivolumab-Induced Hypophysitis
A patient-level synthesis of 40 published cases shows that nivolumab-induced hypophysitis predominantly damages the pituitary's cortisol-regulating axis, responds well to ...
KRAS Blockade Paired with CTLA-4 Therapy Cracks Gastric Cancer Immune Shield
A preclinical study shows that combining KRASG12D inhibition with CTLA-4 blockade dismantles a TGF-beta-driven regulatory T cell shield, sensitizing KRAS-mutant ...
Gut Microbe Transplants May Reverse Immunotherapy Resistance in Liver Cancer
A phase II pilot trial found that a single fecal microbiota transplantation combined with atezolizumab and bevacizumab was safe and ...
Tiny vesicles in cancer patients’ blood rewire T cells and blunt immunity
Plasma-derived small extracellular vesicles from head and neck cancer patients suppress T-cell proliferation, trigger apoptosis, and rewire immune checkpoint expression ...
Indirect Trial Comparison Suggests Retifanlimab Edges Out Avelumab in Metastatic Merkel Cell Carcinoma
A matching-adjusted indirect comparison of two landmark trials suggests retifanlimab significantly prolongs progression-free survival compared with avelumab in metastatic Merkel ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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