Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Tag: p53
Silencing HPV16 Oncogenes E5 and E6 Emerges as a Promising Route Against Cervical Cancer
A new review in Virology Journal examines how siRNA and CRISPR/Cas gene-silencing technologies could target the HPV16 oncoproteins E5 and ...
Early-Life NAD+ Booster Shows Promise for Cognitive Deficits in Schizophrenia Model
A short course of the NAD+ precursor NMN given to young mice in a two-hit schizophrenia model was associated with ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
A Single DNA Letter Tweak Rewires a Cancer Gene’s Translation and Stress Response
A common inherited variant in the DDIT4 3′ UTR controls translation efficiency of the tumor-suppressing stress-response gene, reshaping mTOR signaling, ...
Melatonin May Offer a Surprising Shield Against Skin Cancer, Review Suggests
A new review in the Archives of Dermatological Research proposes that melatonin, through antioxidant, DNA-repair, and circadian mechanisms, may serve ...
Cellular Program Behind Aging May Also Shape Embryos, CHARGE Syndrome Review Suggests
A new review proposes that misregulation of developmental senescence, a transient embryonic cell-arrest program, may contribute to the congenital defects ...
Splicing Factor LUC7L2 Emerges as a Driver of Kidney Damage from Chemotherapy
New research reveals that the RNA splicing factor LUC7L2 drives ferroptotic kidney damage from cisplatin by corrupting the splicing of ...
Scientists Discover the Metabolic Enzyme That Turns Inflammation Into Muscle Wasting
A new Aging Cell study reveals that the inflammatory cytokine TNF-α drives muscle wasting in COPD by activating a p53-Prodh2-mitochondrial ...
A Simple Staining Test Predicts Early Return of Colorectal Cancer After Liver Surgery
A pattern-based p53 immunohistochemistry test identified patients with colorectal liver metastases at nearly four times the risk of early cancer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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