Rare Aggressive Sarcoma Shows Surprising Sensitivity to Targeted Small Molecules in New Lab Study
A new laboratory study shows that desmoplastic small round cell tumor cells are highly vulnerable to histone deacetylase inhibitors, p53 ...
Tag: p53
Cancer’s Guardian Protein Still Pulses After Tiny Radiation Doses, Study Finds
New research shows that the p53 tumour suppressor system in breast cancer cells retains its dynamic, oscillation-like response even at ...
How Losing p53 Lets Mutant Cells Colonize Healthy Tissue: A Wnt Gradient Revealed
A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...
Spit Test for Oral Cancer? Saliva miRNAs and Cell Markers Show Promise in Tobacco Users
A pilot study finds that salivary miR-31-5p and EGFR expression in oral exfoliated cells are dramatically deregulated in tobacco users ...
Ancient Viral Fossils Decoded: New Tool untangles the Human Genome’s Endogenous Retroviruses
A new phylogeny-guided computational tool called ERVmancer resolves the mapping ambiguity of human endogenous retroviruses, revealing locus-level expression patterns in ...
Traditional Chinese Herb Extends Lifespan by Switching On a Cellular Longevity Pathway
A new study in Biogerontology shows that the traditional Chinese herb Erigeron breviscapus extends worm lifespan by up to 18.68 ...
Aging Cells Ratchet Up a Gene Called EYA4, and Silencing It Delays Senescence
New research shows that the age-upregulated gene EYA4 drives cellular senescence by partnering with the transcription factor SIX2 to boost ...
Scientists Discover PTCHD4 as a Novel Driver of Cellular Aging and Age-Related Disease
Researchers have identified the little-studied transmembrane protein PTCHD4 as a novel regulator of cellular senescence whose deletion extends lifespan and ...
STING and p53 Rise in HPV-Linked Skin Cancers, Landmark Study Finds
Researchers in São Paulo report that skin cancers arising in patients with epidermodysplasia verruciformis show markedly higher STING and p53 ...
Cholesterol Enzyme DHCR24 Emerges as Driver and Biomarker of Endometrial Cancer
New research identifies the cholesterol synthesis enzyme DHCR24 as a driver of endometrial carcinoma progression and a potential prognostic biomarker ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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