Stem Cell-Derived T Cells Offer New Human Model for Genotoxicity Testing
Researchers developed an in vitro micronucleus test using human induced pluripotent stem cell-derived T lymphocytes, which showed normal karyotype, intact ...
Tag: p53
Antioxidant Supplement Blunts Radiation-Linked DNA Repair Signals in Interventional Physicians
A pilot clinical study found that a single morning dose of a multi-ingredient oral antioxidant formulation significantly attenuated acute DNA ...
Suppressor tRNAs restore mutant p53 and shrink tumours in mice
Suppressor tRNAs restored full-length p53 from nonsense-mutant TP53 and, delivered via lipid nanoparticles, cut tumour volume by up to 74 ...
Blue laser light plus porphyrin drug pushes lung cancer cells into senescence
A 450-nanometer blue laser combined with the photosensitizer sinoporphyrin sodium suppressed lung cancer cells and xenograft tumors by triggering ROS-dependent ...
p53 Reverses Bcl-2’s Pro-Survival Grip by Restoring MAM Function in Skin Cancer
New research in Cell Division shows that Bcl-2 overexpression promotes survival of cutaneous squamous cell carcinoma cells by altering mitochondria-associated ...
Splicing protein LSM5 linked to aggressive growth in osteosarcoma cells
An integrative analysis finds the splicing protein LSM5 over-expressed across cancers and linked to cell-cycle progression, migration and shorter survival ...
Leukemia cells lacking PTEN reveal a metabolic weakness that approved drugs can exploit
Loss of PTEN makes T-cell acute lymphoblastic leukemia cells dependent on the guanylate-synthesis enzyme IMPDH, allowing clinically approved IMPDH inhibitors ...
ACOT7 fuels head and neck cancer growth by altering arachidonic acid and AKT-MDM2-p53 signaling
A new study reports that elevated ACOT7 promotes malignant phenotypes in head and neck squamous cell carcinoma by raising arachidonic ...
Nanoparticle-delivered Pt(IV) prodrug shows boosted killing of cisplatin-tolerant oral cancer cells in 3D models
A platinum(IV) prodrug covalently attached to mesoporous silica nanoparticles showed significantly greater cytotoxicity than cisplatin in patient-derived oral squamous cell ...
Silver Nanoparticle Shape, Not Just Size, Drives Toxicity in Colon Cancer Cells
Silver nanoparticles shaped as pentagonal nanorods killed colon cancer cells more effectively than similarly sized decahedral particles, according to a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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