Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence
Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...
Tag: p53
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
One Gene, Two Diseases: How a Faulty Ion Transporter Links Dry Mouth and Defective Enamel
New research identifies the ion transporter SLC4A9 as a shared genetic driver of Sjögren's syndrome and amelogenesis imperfecta, linking both ...
Tiny Gene Regulators Show Promise Against the Deadliest Childhood Brain Tumors
New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...
Radiation Turns Childhood Brain Tumor Cells Senescent—and Senolytic Drugs Can Kill Them
New research shows that gamma irradiation drives p53 wild-type medulloblastoma cells into a senescent state that senolytic drugs such as ...
Silencing HPV16 Oncogenes E5 and E6 Emerges as a Promising Route Against Cervical Cancer
A new review in Virology Journal examines how siRNA and CRISPR/Cas gene-silencing technologies could target the HPV16 oncoproteins E5 and ...
Early-Life NAD+ Booster Shows Promise for Cognitive Deficits in Schizophrenia Model
A short course of the NAD+ precursor NMN given to young mice in a two-hit schizophrenia model was associated with ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
A Single DNA Letter Tweak Rewires a Cancer Gene’s Translation and Stress Response
A common inherited variant in the DDIT4 3′ UTR controls translation efficiency of the tumor-suppressing stress-response gene, reshaping mTOR signaling, ...
Melatonin May Offer a Surprising Shield Against Skin Cancer, Review Suggests
A new review in the Archives of Dermatological Research proposes that melatonin, through antioxidant, DNA-repair, and circadian mechanisms, may serve ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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