Cellular Program Behind Aging May Also Shape Embryos, CHARGE Syndrome Review Suggests
A new review proposes that misregulation of developmental senescence, a transient embryonic cell-arrest program, may contribute to the congenital defects ...
Tag: p53
Splicing Factor LUC7L2 Emerges as a Driver of Kidney Damage from Chemotherapy
New research reveals that the RNA splicing factor LUC7L2 drives ferroptotic kidney damage from cisplatin by corrupting the splicing of ...
Scientists Discover the Metabolic Enzyme That Turns Inflammation Into Muscle Wasting
A new Aging Cell study reveals that the inflammatory cytokine TNF-α drives muscle wasting in COPD by activating a p53-Prodh2-mitochondrial ...
A Simple Staining Test Predicts Early Return of Colorectal Cancer After Liver Surgery
A pattern-based p53 immunohistochemistry test identified patients with colorectal liver metastases at nearly four times the risk of early cancer ...
Rare Aggressive Sarcoma Shows Surprising Sensitivity to Targeted Small Molecules in New Lab Study
A new laboratory study shows that desmoplastic small round cell tumor cells are highly vulnerable to histone deacetylase inhibitors, p53 ...
Cancer’s Guardian Protein Still Pulses After Tiny Radiation Doses, Study Finds
New research shows that the p53 tumour suppressor system in breast cancer cells retains its dynamic, oscillation-like response even at ...
How Losing p53 Lets Mutant Cells Colonize Healthy Tissue: A Wnt Gradient Revealed
A Mount Sinai study published in Science shows that loss of the tumor suppressor p53 reorganizes Wnt signaling into a ...
Spit Test for Oral Cancer? Saliva miRNAs and Cell Markers Show Promise in Tobacco Users
A pilot study finds that salivary miR-31-5p and EGFR expression in oral exfoliated cells are dramatically deregulated in tobacco users ...
Ancient Viral Fossils Decoded: New Tool untangles the Human Genome’s Endogenous Retroviruses
A new phylogeny-guided computational tool called ERVmancer resolves the mapping ambiguity of human endogenous retroviruses, revealing locus-level expression patterns in ...
Traditional Chinese Herb Extends Lifespan by Switching On a Cellular Longevity Pathway
A new study in Biogerontology shows that the traditional Chinese herb Erigeron breviscapus extends worm lifespan by up to 18.68 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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