E3 Ligase UBE4B Tags VPS35 for Destruction, Steering Cancer Cell Behavior in Context-Dependent Ways
A new study shows the E3 ligase UBE4B ubiquitinates and degrades VPS35, with opposing effects on cancer cell proliferation and ...
Tag: p53
Lipid nanoparticles bring p53-targeted cancer therapy into focus
A new review argues that lipid nanoparticles, already clinically validated as mRNA carriers, could unify cancer therapy around restoring the ...
Desert date tree bark extract shows DNA damage effects in breast cancer cells
A methanolic trunk bark extract of Balanites aegyptiaca reduced viability and triggered DNA damage in two breast cancer cell lines ...
Herbal compound diosbulbin B worsens doxorubicin liver injury in mice
A new mouse and cell study finds that diosbulbin B, a hepatotoxic constituent of a traditional Chinese medicinal plant, intensified ...
Experimental AMPK activator traps esophageal cancer cells in S phase, priming them for chemotherapy
A laboratory study reports that the AMPK activator AICAR selectively arrests esophageal squamous cell carcinoma cells in S phase through ...
Review Proposes Chronic DNA Damage Signaling as an Aging Framework
A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...
Rare Liver Vascular Tumour Reported for the First Time in a Transplant Graft
A Dublin case report describes the first known hepatic small vessel neoplasm in a liver transplant recipient, detailing how this ...
Ferroptosis framework maps how iron-driven cell death could be pushed or blocked for precision drugs
A new Perspective proposes a unified pharmacological-toxicological framework treating ferroptosis, mitochondrial stress and redox imbalance as one axis governing both ...
Mitochondrial Complex I Emerges as a Resistance-Proof Weak Point in Parasite-Infected Cells
New research shows that inhibiting mitochondrial complex I kills Theileria annulata-infected cells, including drug-resistant ones, and reveals a conserved mitochondrial ...
Scientists Catch Muscle Aging in a Dish: A New Lab Model of Skeletal Muscle Senescence
Researchers at the Federal University of Rio de Janeiro have built a primary chick muscle cell culture model in which ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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