p53 Mutation Predicts Recurrence Even in Non-Invasive High-Grade Endometrial Cancer
A Brazilian study finds that abnormal p53 expression identifies recurrence risk in non-invasive high-grade endometrial cancer, while wild-type tumors show ...
Tag: p53
Pomegranate-Derived Polyphenol Ellagic Acid Boosts Oxaliplatin Against Colorectal Cancer, Study Finds
New research shows the plant polyphenol ellagic acid sensitizes wild-type TP53 colorectal tumors to oxaliplatin by suppressing ATM signaling and ...
First-in-class NVL inhibitors starve tumors by blocking ribosome assembly
Researchers have developed the first selective inhibitors of the NVL ATPase, blocking 60S ribosomal subunit assembly to activate p53 and ...
USP7: The Double-Edged Deubiquitinase That Tumors Cannot Live Without
A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...
AI Reads Live Cell Videos to Predict Cancer Cell Fates Before They Happen
A Transformer deep learning model predicts cancer cell fates directly from live-cell videos with high accuracy up to eight hours ...
Mutant Tau Pushes the Cell’s Protein Factory into Overdrive, Study Finds
New research in Translational Psychiatry shows that disease-associated MAPT mutations drive tau accumulation in the nucleolus, hyperactivating ribosomal DNA transcription ...
Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence
Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
One Gene, Two Diseases: How a Faulty Ion Transporter Links Dry Mouth and Defective Enamel
New research identifies the ion transporter SLC4A9 as a shared genetic driver of Sjögren's syndrome and amelogenesis imperfecta, linking both ...
Tiny Gene Regulators Show Promise Against the Deadliest Childhood Brain Tumors
New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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