Migrasomal miRNA reduces bone loss in mouse osteoporosis model
Pre-osteoblast-derived migrasomes delivered miR-21a-5p to inhibit osteoclast differentiation in cell assays and reduced bone loss in an ovariectomy mouse model.
Tag: osteoblasts
Research report: Advances in probiotics and gut microbiota-derived extracellular vesicles for the prevention and treatment of osteoporosis
A new review details how probiotics, microbial metabolites, and engineered bacterial extracellular vesicles could complement existing osteoporosis therapies through the ...
Systematic review maps ellagic acid’s bone effects in preclinical models
A systematic review of 13 cell and animal studies reports bone-protective effects of ellagic acid in preclinical osteoporosis models, but ...
Hidden Protein Switches That Keep Bones in Balance May Reshape Osteoporosis Research
A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...
Single-cell and bulk transcriptomic characterization of the osteosarcoma microenvironment reveals lineage-specific programs and inflammatory differences associated with metastasis
Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...
Hidden RNA switches that control the cellular recycling behind bone loss
A new review maps how microRNAs, long non-coding RNAs and circular RNAs tune autophagy in bone cells, opening a fresh ...
How Exercise Reprograms Glucose Metabolism to Fight Osteoporosis
A new review reveals that exercise protects against osteoporosis by reprogramming how bone cells burn glucose, linking glycolysis, lactate signaling, ...
Senolytic Drugs Show Promise Against Bone Loss Caused by Chemotherapy
A new mouse study shows that senolytic drugs targeting senescent cells can partially mitigate the bone loss and marrow fat ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Cell Death Debris Turns Out to Be a Master Regulator of Bone Renewal
A new review in the Journal of Translational Medicine details how vesicles released by dying cells actively regulate bone remodeling ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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