Bone-aging study links R-loop buildup to osteoblast DNA damage
A new study in Cell Death Discovery shows that the PRMT6–SIRT5–HADHA pathway protects bone-forming osteoblasts from R-loop-induced DNA damage during ...
Tag: osteoblasts
From Brittle Bones to Gene Editing: New Map of Osteogenesis Imperfecta and Its Therapies
A new review maps how mutations in more than twenty genes weaken bone in osteogenesis imperfecta and surveys therapies from ...
Bone Damage Runs Deep in Cushing’s Syndrome, Even When Scans Look Normal
A new review explains why fractures strike Cushing's syndrome patients with normal bone density and why risk persists years after ...
Long Non-Coding RNA MALAT1 Emerges as a Multifaceted Regulator of Bone Remodeling
A new narrative review synthesizes preclinical evidence that the long non-coding RNA MALAT1 influences osteoblast differentiation, osteoclast formation and bone ...
Semaglutide shows early bone-building signal in male mice study
An exploratory mouse study found that 28 days of semaglutide exposure significantly increased the osteoblast-covered bone surface without detectable changes ...
Review frames Wnt/β-catenin as a metabolic hub linking traditional Chinese medicine to osteoporosis
A new review proposes osteoblast metabolic senescence as a key driver of osteoporosis and outlines how traditional Chinese medicine might ...
HIV Viral Proteins Alone Drive Bone Loss in Transgenic Mice
A mouse study finds that constitutive HIV-1 viral protein expression, without viral replication or antiretroviral drugs, is associated with early-onset ...
Mushroom Polysaccharide and Plant Phenolic Show Promise Against Steroid-Induced Bone Loss in Mice
A mushroom-derived polysaccharide and a simple plant phenolic compound each reduced bone deterioration in a preclinical mouse model of glucocorticoid-induced ...
Natural coumarins from Qinpi rebalance bone cells to fight osteoporosis in mice
Eculin and esculetin, coumarins from the traditional medicine Qinpi, simultaneously stimulate bone-forming osteoblasts and suppress bone-resorbing osteoclasts in mice, offering ...
Migrasomal miRNA reduces bone loss in mouse osteoporosis model
Pre-osteoblast-derived migrasomes delivered miR-21a-5p to inhibit osteoclast differentiation in cell assays and reduced bone loss in an ovariectomy mouse model.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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