Age Rewrites the Brain Rules of Early Multiple Sclerosis, Five-Year Study Finds
A five-year prospective study of people after a first demyelinating event found that age modifies the link between cognitive impairment ...
Tag: neurodegeneration
Blood Protein Test Predicts Seven Years of Nerve Damage in Rare Genetic Disease
A seven-year Dutch study shows that a single baseline blood measurement of neurofilament light chain predicts the pace of spinal ...
Clinical Risk Scores Cannot Stand In for Neurofilament Biomarkers in ALS Trials, Study Finds
A reanalysis of the MIROCALS trial shows that the TRICALS clinical risk score adds useful prognostic information in ALS but ...
Lifting Weights May Rejuvenate the Aging Brain’s Metabolism and Deepen Sleep
A randomized trial in GeroScience found that twelve weeks of explosive resistance training lowered resting lactate in the sensorimotor cortex ...
Blood Protein Tracks Early Multiple Sclerosis Damage, But MRI Still Holds the Prognostic Edge
A five-year analysis of early multiple sclerosis patients shows that a single baseline blood neurofilament measurement predicts disease progression only ...
Cellular Recycling Pathway Emerges as Central Driver of Ageing and Disease
A new review argues that chaperone-mediated autophagy, the cell's most selective protein degradation pathway, acts as a master regulator of ...
Human GLUD2 Gene Variant Worsens Parkinson’s Disease by Igniting an Astrocyte–Microglia Complement Cascade
A human-specific GLUD2 gene variant worsens Parkinson's disease pathology in mice by driving complement C3 signaling from astrocytes to microglia, ...
Scientists Map the Iron Recycling Switch That Decides Whether Cells Live or Die
A new review in the Journal of Translational Medicine maps how NCOA4-mediated ferritinophagy controls iron release and ferroptosis, cataloguing small-molecule ...
Naked Mole Rats Park Fat in Brain Immune Cells to Shield Neurons from Aging
A comparative study finds that naked mole rats store far more fat in microglia and keep neuronal lipid droplets stable ...
Ancient enzyme TyrRS may schedule nightly DNA repair in neurons, and aging breaks the clock
A new GeroScience review proposes that the tyrosine-sensing enzyme TyrRS schedules neuronal DNA repair across the sleep-wake cycle, and that ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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