Blood and Spinal Fluid Markers of Alzheimer’s Track Brain Plaques in a Strict Sequence
A large autopsy-validated study shows that cerebrospinal fluid and plasma Alzheimer's biomarkers become abnormal in a defined sequence as amyloid-beta ...
Tag: neurodegeneration
Huntington’s Disease Damages Brain Arterioles, but S1PR1 Stimulation Offers Reversal
A new Nature Communications study shows that Huntington's disease damages brain arterioles in a barrier-type-selective pattern coupled to reactive astrogliosis, ...
Synaptotagmins: How Calcium-Sensing Proteins Decide Whether Neurons Thrive or Die
A sweeping review of all seventeen mammalian synaptotagmin proteins reveals how failures in calcium-sensing vesicle fusion machinery can cascade from ...
Somatic SNCA Gene Gains in Glia Drive Multiple System Atrophy
Researchers have shown that somatic copy number gains of the SNCA gene accumulate in oligodendrocytes of multiple system atrophy brains, ...
Oral Sodium Butyrate Shows Promise in Protecting Brain Cells in Parkinson’s Rat Model
A new rat study shows that four weeks of oral sodium butyrate treatment significantly improves motor function and preserves dopaminergic ...
Baby Reflexes That Return in Old Age May Signal Failing Minds, Study Finds
New research shows that the reappearance of infantile primitive reflexes in older adults strongly predicts poorer cognitive functioning and lower ...
Brain stimulation may restore function—or amplify the brain’s own workarounds
Boston University researchers propose that brain stimulation should sometimes amplify the brain's own compensatory workarounds rather than always restoring normal ...
Scientists Map a Grand Plan to Decode the Microtubule Cytoskeleton in Health and Disease
A new Roadmap in Nature Reviews Molecular Cell Biology outlines how integrating structural biology, biophysics, computation and medicine can finally ...
Lonely Sleep Waves: How Tau Tangles Quietly Sabotage the Aging Brain’s Memory.
New research shows that frontal tau pathology fragments the traveling slow waves of deep sleep, weakening overnight memory consolidation and ...
APOE and neuromelanin shape Alzheimer’s risk in human brain’s stress hub
Deep in the brainstem, a tiny, pigment-darkened cluster of neurons called the locus coeruleus acts as the brain's principal source ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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