Losing cGAS Drives Microglial Decline and Progressive Neurodegeneration in Mice
A new mouse study finds that losing cGAS disrupts microglial homeostasis and drives progressive neurodegeneration from early adulthood.
Tag: neurodegeneration
Phase 2b trial of neflamapimod in dementia with Lewy bodies fails to replicate earlier promise
A phase 2b randomized trial found no benefit of neflamapimod on the primary CDR-SB outcome in dementia with Lewy bodies, ...
MRI study maps two sequences of brain barrier leaks and thinning in cognitive impairment
A SuStaIn analysis of DCE-MRI and structural MRI data from 216 participants identified atrophy-first and BBB-first subtypes with distinct cognitive ...
Circular RNA circSMOX Emerges as a Player in Muscle and Nerve Disease
A new mini review in Amino Acids summarizes what is known about the circular RNA circSMOX, which is upregulated in ...
Tea Catechins and Cocoa Flavanols May Complement Exercise in Brain Aging, Review Finds
A narrative review suggests green tea catechins and cocoa flavanols may support exercise-induced adaptations in brain aging through distinct mitochondrial ...
SOD1 Aggregates Injected into Brain Fluid Trigger ALS in Mice
Injecting two strains of misfolded human SOD1 aggregates into the cerebrospinal fluid of transgenic mice triggered prion-like aggregation and fatal ...
Src kinase emerges as a molecular player in early tau pathology in Alzheimer’s disease
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
ADP-ribose, an NAD+ catabolite, drives neuronal ferroptosis through ENT2 inhibition
A new Nature Chemical Biology study identifies the NAD+ catabolite ADP-ribose as an inducer of neuronal ferroptosis through inhibition of ...
Astrocyte Lipid Metabolism Emerges as a Central Player in ALS Progression
A new review argues that disrupted lipid handling in astrocytes may amplify motor neuron injury and disease progression in ALS.
Blood–Brain Barrier Breakdown Speeds Alzheimer’s-Like Damage in Fruit Flies
Knocking down the receptor moody in Drosophila barrier glia increased permeability and, together with human amyloid-beta expression, worsened neurodegeneration without ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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