Experimental Drug DNL343 Fails to Slow ALS Progression in Randomized Trial
A randomized clinical trial in JAMA Network Open found that 200 mg per day of DNL343, an eIF2B activator, did ...
Tag: neurodegeneration
Dementia Brain Rewires Itself to Keep Stepping Fast, fNIRS Study Reveals
A new fNIRS study shows that older adults with dementia reorganize their prefrontal networks into more segregated local clusters, and ...
The Don’t Eat Me Signal: How CD47 Shapes Cell Clearance in Cancer, Heart Disease and the Brain
A new review details how the CD47 don't eat me signal regulates efferocytosis and shapes disease outcomes in cancer, atherosclerosis ...
Plant Compounds Show Promise Against Toxic Protein Clumps in Brain Disease
A comprehensive review in 3 Biotech details how plant-derived compounds such as polyphenols, flavonoids, and alkaloids can inhibit the toxic ...
Cholesterol-Tipped Gene Silencers Rescue Failing Neurons in Parkinson’s Mice
A new study shows that cholesterol-conjugated heteroduplex oligonucleotides can silence alpha-synuclein in the mouse brain, protecting dopaminergic neurons through the ...
Tau Filaments Act Like Prions, Imposing Their Disease Signature on Mouse Brains
Injecting tau filaments from Alzheimer's and corticobasal degeneration patients into wild-type mice induces endogenous tau pathologies with identical folded structures, ...
Hidden Androgen Receptor Isoform Shows Promise Against Kennedy’s Disease
A naturally occurring short isoform of the androgen receptor, AR-A, dramatically reduces aggregation and toxicity of the mutant protein causing ...
Sex Chromosomes Direct Cancer, Heart Health, and Longevity
A new review in Science reveals that X and Y chromosomes independently shape disease risk and aging, offering a new ...
Hidden Brain Protein Reveals New Cell Death Pathway After Concussion
Researchers report that the trafficking protein Snapin drives neuronal PANoptosis after mild traumatic brain injury by disrupting hydrogen sulfide signaling ...
Old Blood Pressure Drug Shows Promise Against Huntington’s Disease Chorea
A phase 2b European trial found that SOM3355, a repurposed beta-blocker with a novel triple mechanism, significantly reduced chorea in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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