Troubled Cholesterol Particle L5 Linked to Fading Language Networks in Early Cognitive Decline
A new GeroScience study finds that elevated levels of electronegative L5 cholesterol are associated with weakened connectivity in the brain's ...
Tag: neurodegeneration
MS Severity Gene Variant Also Tied to Slower Thinking in Healthy Adults, UK Biobank Study Finds
A genetic variant linked to faster multiple sclerosis progression is associated with subtly poorer reaction time, fluid intelligence and prospective ...
Cellular Antenna Turned Metabolic Command Center: How Primary Cilia Reshape Health and Disease
A new review redefines the primary cilium as a dynamic sensory-metabolic hub whose disruption contributes to cardiovascular, reproductive, metabolic, cancer ...
ERC Starting Grants Fund Frankfurt Projects on Global Finance and Cell Aging
Goethe University Frankfurt researchers Johannes Petry and Seda Koyuncu have each won an ERC Starting Grant worth up to 1.5 ...
Blood Pressure Drug Diltiazem Shows Promise Against Childhood Dementia
New research shows that the calcium channel blocker diltiazem suppresses parthanatos-related DNA damage and poly(ADP-ribose) accumulation in patient-derived cells from ...
Gene Behind Hereditary Spastic Paraplegia Linked to Rare Plaque-Only Dementia
An international study of 726 patients links novel SPG4/SPAST mutations to a rare plaque-only form of early-onset dementia, expanding the ...
Three Blood Biomarkers Together Predict ALS Progression and Survival, Study Finds
A longitudinal study of 100 ALS patients shows that combined serum levels of 4-HNE, LBP, and NfL discriminate rapid disease ...
Single-Cell Map Reveals Why Some Cholinergic Neurons Age Faster Than Others
Single-nucleus RNA sequencing of the mouse brain reveals that basal forebrain cholinergic neurons undergo uniquely damaging stress-related transcriptional changes with ...
Common Antidepressants Disrupt the Sleep Paralysis That Keeps Dreamers Still
A large Cleveland Clinic study of 1,474 sleep studies found that SSRIs and SNRIs, but not tricyclic antidepressants, are associated ...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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