Hantavirus spike structure reveals recessed protocadherin-1 binding pocket
A near-atomic-resolution structure shows how a recessed pocket assembled from four hantavirus glycoproteins recognizes protocadherin-1 and how two distinct classes ...
Tag: mutagenesis
Molecular dynamics and cell experiments identify third Kv4.3–KChIP1 interface
Molecular dynamics and electrophysiology experiments identify a salt-bridge-rich third interface that stabilizes Kv4.3–KChIP1 complexes and supports potassium-channel tetramerization.
Hidden Chemical Tag on Zika Protein Revealed as Key to Viral Secretion
Researchers at Radboud University Medical Center report that prolyl hydroxylation of Zika virus NS1 is essential for the protein's maturation ...
Cesium and Glycine Switch On the Brain’s Inhibitory Glycine Receptor Through the Same Molecular Machinery, Study Finds
New mutagenesis and patch-clamp experiments reveal that cesium ions activate the RNA-edited glycine receptor α3L through the same structural framework ...
Zebrafish Genetic Engineering Enters a New Era of Precision Gene Control
A new review charts how zebrafish genetic engineering has evolved from random chemical mutagenesis to precise, reversible CRISPR-based gene control ...
DyME: A New Engine Automates Thousands of Protein Simulations for Molecular Design
Researchers have developed DyME, an open-source platform that automates high-throughput mutagenesis, molecular dynamics simulation, and comparative analysis of thousands of ...
Mutations Give RNA Droplets Their Own Genes, Vacuoles and Movement
Researchers have shown that RNA droplets trap their own DNA templates, and that even low rates of mutation produce stable ...
Barcode-Based Mutagenesis Assay Reveals Strand-Bias Rules Behind Oxidative DNA Damage
A barcoded shuttle-vector sequencing assay shows that chronic low-dose gamma irradiation amplifies pre-existing mutation hotspots driven by a single 8-oxo-G ...
Electron Beam Mutagenesis Unlocks New Yield Potential in Field Corn
Indian researchers used high energy pulse electron beam irradiation to create genetically diverse maize mutants with improved cob and kernel ...
MutexaGPT: an intuition-to-design translator for physics-based enzyme engineering
A new framework called MutexaGPT aims to translate scientists' mechanistic intuitions into physics-grounded enzyme designs, combining large language models with ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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