Nitrogen Ion Beam Mutagenesis Boosts Sophorolipid Output in Starmerella bombicola
Nitrogen ion beam mutagenesis produced stable Starmerella bombicola mutants, one of which yielded 224.31 g/L of total sophorolipids in a ...
Tag: mutagenesis
Hydrophobic loop remodeling weakens ACE2 binding in SARS-CoV-2 JN.4
Cryo-EM and functional assays show that the JN.4-specific A475V substitution remodels the SARS-CoV-2 RBD large loop and reduces ACE2-binding affinity ...
Wheat Gene Knockouts Deliver Upright Leaves Without Yield Penalties
Knocking out the wheat brassinosteroid biosynthesis gene DWARF4 produces an upright leaf canopy with only mild height reduction and no ...
Engineered RepE Variants Tune Plasmid Copy Number in Bacteria
Two point mutations in the F-plasmid initiator protein RepE were found to increase the copy number of plasmid pFO1 in ...
Hantavirus spike structure reveals recessed protocadherin-1 binding pocket
A near-atomic-resolution structure shows how a recessed pocket assembled from four hantavirus glycoproteins recognizes protocadherin-1 and how two distinct classes ...
Molecular dynamics and cell experiments identify third Kv4.3–KChIP1 interface
Molecular dynamics and electrophysiology experiments identify a salt-bridge-rich third interface that stabilizes Kv4.3–KChIP1 complexes and supports potassium-channel tetramerization.
Hidden Chemical Tag on Zika Protein Revealed as Key to Viral Secretion
Researchers at Radboud University Medical Center report that prolyl hydroxylation of Zika virus NS1 is essential for the protein's maturation ...
Cesium and Glycine Switch On the Brain’s Inhibitory Glycine Receptor Through the Same Molecular Machinery, Study Finds
New mutagenesis and patch-clamp experiments reveal that cesium ions activate the RNA-edited glycine receptor α3L through the same structural framework ...
Zebrafish Genetic Engineering Enters a New Era of Precision Gene Control
A new review charts how zebrafish genetic engineering has evolved from random chemical mutagenesis to precise, reversible CRISPR-based gene control ...
DyME: A New Engine Automates Thousands of Protein Simulations for Molecular Design
Researchers have developed DyME, an open-source platform that automates high-throughput mutagenesis, molecular dynamics simulation, and comparative analysis of thousands of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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