MMP1 Emerges as a Shared Molecular Link Between Gout and Severe COVID-19
A combined bioinformatics and molecular simulation study identifies MMP1 as a shared hub gene and colchicine target linking gout and ...
Tag: molecular docking
Fungus from medicinal cactus reveals chemical arsenal against rival molds
Deep inside the stem of a spiny medicinal cactus, a microscopic fungus has been waging chemical warfare on its rivals ...
AI Drug Discovery Gets a Virology Check: Why Respiratory Virus Polymerases Break the Benchmarks
A new review argues that AI-driven antiviral discovery must be benchmarked against respiratory RNA virus polymerases under virologically realistic conditions ...
Milk Thistle Compound Silymarin Blocks Stomach Bacterium in Lab Tests
A new study shows that silymarin, the flavonolignan complex from milk thistle, kills Helicobacter pylori, suppresses key inflammatory mediators, and ...
Shared Molecular Signatures Link Deadly Lung Disease to Aggressive Cancer
Idiopathic pulmonary arterial hypertension (IPAH) has long puzzled physicians... The methodological architecture of the study deserves closer examination, because the ...
Computational Design Points to New Indolinone Drug Candidates Against Cancer
Researchers have computationally designed ten novel indolinone-based anticancer candidates and prioritized two, Pred 9 and Pred 10, as potential MEK1 ...
Mild Silicon Catalyst Turns Classic Reaction Into Assembly Line for New Alzheimer’s Drug Candidates
Chemists have used a mild silicon catalyst to rapidly build dihydropyrimidinethione compounds that inhibit the cholinesterase enzymes implicated in Alzheimer's ...
Scaffold Hopping Yields New Histamine H3 and H4 Receptor Ligands
Medicinal chemists... The histamine receptor family offers a striking example of how a single small molecule can orchestrate profoundly different ...
Scientists Use Immune Informatics to Sketch a First Vaccine Blueprint Against Human Metapneumovirus
A computational reverse vaccinology study has designed BAFF- and APRIL-adjuvanted multi-epitope vaccine candidates against human metapneumovirus, a major respiratory pathogen ...
Designer Molecules That Outperform Vitamin C Could Keep Fresh Beef Red for Longer
Chemists synthesized ten indole-thiosemicarbazide hybrids, with one compound outperforming vitamin C in radical-scavenging assays and preserving the red color of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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