Computational study prioritizes two benzohydrazide derivatives for EGFR testing
A computational and synthesis study prioritized benzohydrazide compounds 3d and 3f for experimental EGFR testing, while the lack of biological ...
Tag: molecular docking
Alkaloids from Erythrina crista-galli flowers inhibit acetylcholinesterase
Four alkaloids isolated from Erythrina crista-galli flowers inhibited acetylcholinesterase in vitro, with cristamidine showing the strongest activity and stable modelled ...
Ultrasound speeds synthesis of theophylline hybrids with antibacterial activity
An ultrasound-assisted click reaction generated ten theophylline–triazole acetamide hybrids in 55 minutes, with four halogenated compounds showing the strongest activity ...
Pathogenic ABCC8 variants mostly preserve gliclazide binding, simulations show
Computational simulations found that pathogenic ABCC8 variants generally preserved gliclazide binding, while producing variant-specific changes in structural stability and predicted ...
Nuciferine reduces bladder-cancer tumor growth in mice, study finds
A small mouse xenograft study found that chemically characterized nuciferine from lotus leaves reduced bladder-cancer tumor growth alongside apoptosis-related changes ...
Integrated computational screening and biochemical validation identify natural small molecules targeting Aβ aggregation and dissociation
A computational screen followed by cell-free Aβ42 assays identified four Jowiseungchungtang-derived small molecules that inhibited aggregation, with two also reducing ...
Ketoprofen–thiazolidinone hybrids reduce inflammation in mouse paw edema
A study of synthesized ketoprofen–thiazolidin-4-one hybrids found that AR3 reduced mouse paw edema more consistently than ketoprofen at later time ...
Research report: Physiological and biophysical evidence associates FeRbohB with rutin-mediated responses to PEG-simulated water deficit during common buckwheat germination
A multi-method study links FeRbohB with rutin-associated responses in common buckwheat under PEG-simulated water deficit but does not establish a ...
Sea anemone bacterium shows multi-target activity in vitro
Genome analysis and laboratory assays found antioxidant, anti-inflammatory, antidiabetic and antiproliferative activity in a Brevibacterium sanguinis strain isolated from a ...
Plant Extract Shows Dual Potential Against Skin-Aging Enzymes
An Ardisia elliptica leaf extract inhibited collagenase and elastase in laboratory assays, while molecular docking highlighted fatty acids and phenolics ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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