A multi-omics study identified gut microbial dysbiosis and plasma metabolic reprogramming in patients with drug-induced liver injury, revealing exploratory candidate ...
Researchers found that cigarette smoke elevates epithelial TALDO1, driving kynurenine accumulation that disrupts mitochondria and promotes chronic lung injury.
Researchers have discovered that the metabolic enzyme HMGCS1 accumulates in the mitochondria of cervical cancer cells to promote cisplatin resistance ...
Researchers identified the metabolic gene ARG2 as a central driver of inflammatory tissue damage and neutrophil extracellular traps in sepsis-induced ...
An integrative multi-omics analysis links higher FADS3 expression to increased hepatocellular carcinoma risk, tumor-stromal crosstalk with cancer-associated fibroblasts, and adverse ...
A systematic review indicates that combining novel molecular markers with pathway-targeted therapies improves diagnosis, prognostic stratification, and individualized treatment in ...
A functional study of a homozygous PKLR mutation reveals that divergent N-termini cause aberrant phosphorylation in erythrocyte PKR and metabolic ...
A study in Discover Oncology finds that silencing TPX2 suppresses glycolysis and malignant traits in colorectal cancer cells, with PKM2 ...
In preclinical mouse models, inhibiting glutaminase 1 attenuated chronic kidney disease–induced cardiac hypertrophy driven by metabolic reprogramming and mitochondrial dysfunction.
A comprehensive review examines how oral microbial dysbiosis promotes gastric inflammation, immune evasion, and metabolic reprogramming while highlighting novel diagnostic ...
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