Fat-Filled Droplets Power the Deadliest Childhood Brain Tumours
New research shows that high-risk Group 3 and Group 4 medulloblastoma cells accumulate cholesterol ester-rich lipid droplets that support energy ...
Tag: metabolic reprogramming
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Viral protein hijacks a metabolic enzyme to drive Kaposi’s sarcoma spread
Researchers have shown that the KSHV protein vIRF3 binds and activates the metabolic enzyme PKM2, raising acetyl-CoA levels that drive ...
How Lung Cancer Rewires Fat Metabolism to Grow, Spread, and Evade Treatment
A new review in the Journal of Translational Medicine maps how non-small cell lung cancer rewires lipid metabolism to fuel ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
A Lipid Dial May Decide Whether Bile Duct Cancer Cells Live or Die by Ferroptosis
A new review proposes that the ratio of monounsaturated to polyunsaturated membrane phospholipids acts as a tunable rheostat controlling ferroptosis ...
Sugar Metabolism Emerges as a Master Switch Controlling Bone Rebuilding
A new review argues that glycolysis acts as a signaling hub in bone remodeling, with glycolytic enzymes and metabolites such ...
Gut Viruses May Act as Ecological Amplifiers of Colorectal Cancer
A new review proposes that bacteriophages in the gut virome act as ecological amplifiers, translating environmental disturbances into bacterial reprogramming ...
Blood Metabolites Emerge as Powerful New Signals for Predicting Cancer Outcomes
A new review maps how advances in plasma metabolomics detection technology are turning tumor-driven metabolic fingerprints in blood into tools ...
How Tumor Mitochondria Help Cancer Hide From the Immune System
A new review in the Journal of Translational Medicine details how mitochondrial metabolic reprogramming in tumor cells drives immune evasion ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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