TPX2 Silencing Reduces Glycolysis and Malignant Traits in Colorectal Cancer Cells
A study in Discover Oncology finds that silencing TPX2 suppresses glycolysis and malignant traits in colorectal cancer cells, with PKM2 ...
Tag: metabolic reprogramming
Inhibiting GLS1 Attenuates Kidney Disease Induced Cardiac Hypertrophy in Male Mice
In preclinical mouse models, inhibiting glutaminase 1 attenuated chronic kidney disease–induced cardiac hypertrophy driven by metabolic reprogramming and mitochondrial dysfunction.
Oral Bacteria Migration Linked to Gastric Carcinogenesis and Altered Therapy Response
A comprehensive review examines how oral microbial dysbiosis promotes gastric inflammation, immune evasion, and metabolic reprogramming while highlighting novel diagnostic ...
Review Identifies Chaperone-Mediated Autophagy as Context-Dependent Node in Breast Cancer
A review in Cell Communication and Signaling characterizes chaperone-mediated autophagy as a context-dependent proteostatic decision node influencing breast cancer progression, ...
Inherited Prostate Cancer Genetic Risk Redistributes Across Niches During Disease Progression
An integrative multi-omics analysis of patient tissues reveals that inherited prostate cancer genetic risk redistributes from epithelial niches to stromal ...
Endoplasmic Reticulum Stress Adaptation Drives Treatment Resistance in Multiple Myeloma
A scientific review highlights how endoplasmic reticulum stress pathways and unfolded protein response signaling enable multiple myeloma cells to resist ...
Ketone Body β-Hydroxybutyrate May Modulate Stress Pathways in Kidney Disease Review
A review in BMC Nephrology examines how ketone body metabolism and β-hydroxybutyrate influence renal disease through signaling mechanisms, epigenetic modifications, ...
Ceramide Loss Accelerates Gastric Cancer Malignancy Through Diminished ALPP Inhibition
A multi-omics study demonstrates that down-regulated ceramides accelerate gastric cancer malignancy by failing to inhibit the pro-tumor protein ALPP.
Review Connects Metabolic Reprogramming and Epigenetics to Chemotherapy-Induced Nerve Damage
A scientific review outlines a framework linking systemic metabolic reprogramming, receptor signaling, and epigenetic modifications to the persistence of chemotherapy-induced ...
Cuproptosis Suppression Score Predicts Immunotherapy Responses in Clear Cell Renal Carcinoma
Researchers developed a cuproptosis suppression score that correlates with oncogenic signaling pathways and accurately predicts immunotherapy responses in clear cell ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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