Four Metabolic Genes Predict Survival in Aggressive Liver Cancer
Researchers have built and validated a four-gene metabolic signature that predicts survival in intrahepatic cholangiocarcinoma more accurately than standard clinical ...
Tag: metabolic reprogramming
Macrophage Exosomes Disarm Immune Cells and Fuel Ovarian Cancer Spread
A new study shows that exosomes released by tumor-associated macrophages carry PD-L1 that reprograms the metabolism of CD8-positive T cells, ...
Rewiring the Engine: How Metabolism Could Unlock CAR-T Cells for Solid Tumors
A new review argues that engineering the metabolism of CAR-T cells, alongside neutralizing the hostile chemistry of tumors, is the ...
Weight Loss Rewires Cholesterol Metabolism, but Tiny RNAs Are Not the Driver
A Dutch randomized trial finds that diet-induced weight loss shifts cholesterol metabolism in abdominally obese men from a synthesizing to ...
How Microglial Metabolism and Mitochondria Drive Brain Damage After Stroke
A new review integrates mitochondrial quality control, metabolic reprogramming, and NLRP3 inflammasome activation into a single framework explaining how microglia ...
Hidden Mitochondrial Transporters May Expose New Vulnerabilities in Colorectal Cancer
A new review highlights how three mitochondrial metabolite transporters are deregulated in colorectal cancer and jointly shape tumor metabolism, epigenetic ...
Neurexophilin 4 Emerges as a Molecular Driver of Kidney Cancer Through PI3K/AKT-Controlled Glycolysis
New research reveals that the protein neurexophilin 4 drives the growth, invasion and metabolic reprogramming of clear cell renal cell ...
Aerobic Glycolysis Emerges as a Key Driver of TGF-β-Induced EMT in Lung Cells
New research in Cell Death Discovery examines how aerobic glycolysis supports TGF-β-induced epithelial-to-mesenchymal transition in lung epithelial cells.
RUNX3 Emerges as a Master Switch Behind Cancer Chemoresistance
A new review in Cancer Cell International details how the tumor suppressor RUNX3 regulates apoptosis, drug efflux, cell cycle control, ...
Chemotherapy’s Hidden Survivors: Lactylation Switch Reveals How Colorectal Cancer Cells Hide From Treatment
A new Molecular Cancer study reveals how UQCRC2 lactylation and SIRT1-driven mitophagy allow colorectal cancer cells to survive chemotherapy in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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