Hidden Mitochondrial Transporters May Expose New Vulnerabilities in Colorectal Cancer
A new review highlights how three mitochondrial metabolite transporters are deregulated in colorectal cancer and jointly shape tumor metabolism, epigenetic ...
Tag: metabolic reprogramming
Neurexophilin 4 Emerges as a Molecular Driver of Kidney Cancer Through PI3K/AKT-Controlled Glycolysis
New research reveals that the protein neurexophilin 4 drives the growth, invasion and metabolic reprogramming of clear cell renal cell ...
Aerobic Glycolysis Emerges as a Key Driver of TGF-β-Induced EMT in Lung Cells
New research in Cell Death Discovery examines how aerobic glycolysis supports TGF-β-induced epithelial-to-mesenchymal transition in lung epithelial cells.
RUNX3 Emerges as a Master Switch Behind Cancer Chemoresistance
A new review in Cancer Cell International details how the tumor suppressor RUNX3 regulates apoptosis, drug efflux, cell cycle control, ...
Chemotherapy’s Hidden Survivors: Lactylation Switch Reveals How Colorectal Cancer Cells Hide From Treatment
A new Molecular Cancer study reveals how UQCRC2 lactylation and SIRT1-driven mitophagy allow colorectal cancer cells to survive chemotherapy in ...
Root anatomy, metabolism and microbes team up to help plants survive nutrient scarcity
University of Nottingham scientists have shown that root anatomy, metabolic reprogramming and microbial colonisation work together to let plants reshape ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
Lactate Overload Blocks Kidney Recovery by Crippling Mitochondria Through MRS2
A new study shows that lactate accumulating during reperfusion drives maladaptive metabolic reprogramming in acute kidney injury by triggering MRS2-dependent ...
Stress-Triggered RNA Molecule Helps Lung Cancer Cells Rewrite Their Fuel Supply
Researchers have identified an energy-stress-induced long non-coding RNA called GIRGL that drives glucose metabolism reprogramming in lung adenocarcinoma by interacting ...
Argininosuccinate Signal Fuels Carbon Replenishment in Leukaemia Cells
New research in Nature Metabolism shows that phosphorylated ASS1 in B cell acute lymphoblastic leukaemia produces argininosuccinate, which activates NT5C2 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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