Immune Receptor LAIR1 Blocks Cancer Cell Engulfment in Brain Tumours
New research in the British Journal of Cancer shows that the collagen-binding receptor LAIR1 disables the phagocytic machinery of glioma-associated ...
Tag: macrophages
Single-cell atlas of human liver pinpoints scar macrophages as drug target for fibrosis
A 649,295-cell single-cell atlas of human livers has revealed a pro-inflammatory OLR1-positive scar-associated macrophage population that expands across chronic liver ...
Fibronectin found to reprogram immune cells and drive tooth regeneration
Researchers have shown that the matrix protein fibronectin reprograms macrophages in damaged dental pulp into pro-angiogenic cells, enhancing blood vessel ...
Blocking EP300 Rewires Scar-Associated Macrophages to Fight Acute Liver Failure
A new Nature Communications study shows that inhibiting the epigenetic enzyme EP300 restores the antibacterial function of scar-associated macrophages by ...
Microplastics Overwhelm Liver Immune Cells and Derail Metabolism in Mice
A twelve-week mouse study shows that microplastics and nanoplastics accumulate in liver macrophages and disrupt metabolism in strikingly different ways ...
Chemical Tag on mRNA Supercharges Scavenger Cells to Heal Dangerous Liver Abscesses
New research shows that the m6A-writing enzyme METTL3 speeds recovery from bacterial liver abscesses by methylating Nrf2 mRNA, which arms ...
Sugar Switch on Immune Cells Could Push Macrophages Back Into Cancer-Fighting Mode
Researchers found that blocking the enzyme ST6GAL1 reverses a sugar-linkage switch on macrophages, restoring tumor-fighting behavior and slowing colorectal cancer ...
Scientists Reveal the Cellular Dialogue That Scars Nasal Polyps From Within
A new study integrates single-cell transcriptomics with human tissue and mouse model validation to show that TGF-beta/Smad-driven dialogue between epithelial ...
Immune Protein CD37 Blocks Leg Muscle Healing in Artery Disease
New research shows that the immune surface protein CD37 drives inflammatory macrophage activity that impairs blood vessel regrowth and muscle ...
Transplant Drug Rewires Prostate Tissue in Two Distinct Phases, Rat Study Finds
A new rat study shows the immunosuppressant mycophenolate mofetil dismantles prostate stromal fibers in two timed phases, reshaping collagen, immune ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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