Immune Enzyme PTPN2 Emerges as Master Switch in Sepsis Inflammation
McGill University researchers have identified the enzyme PTPN2 as a key regulator of non-canonical inflammasome activation, revealing how it shapes ...
Tag: macrophages
Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors
A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...
Mitochondrial Quality Genes Yield Seven-Gene Prognostic Signature for Breast Cancer
Researchers report that mitochondrial quality regulation gene activity defines two prognostically distinct breast cancer subtypes and supports a seven-gene survival ...
How a Single Amino Acid Pathway May Steer Autoimmune Disease
A new review in the Journal of Translational Medicine details how the glutamine-glutamate metabolic axis regulates immune cell fate and ...
Nanovaccine Built From Metal–Organic Frameworks Drives Tumours Into Full Retreat
A metal–organic framework nanovaccine co-delivering tumour antigens and STING agonists induced systemic tumour regression, immune memory and synergy with radiotherapy ...
A Common Amino Acid Throws a Molecular Wrench Into the Body’s Inflammation Machine
New research shows the dietary amino acid l-arginine directly binds the NLRP3 inflammasome and blocks its assembly, easing inflammatory and ...
Inflammation-Driven Spatial Niche Sets the Stage for Early Gastric Cancer
A spatial multi-omics study in Chinese Medical Journal shows that early gastric cancer arises within an inflammation-associated spatial niche governed ...
A Simple Blood Protein Could Reveal How Aggressive Advanced Prostate Cancer Will Be
Danish researchers report that elevated serum levels of the macrophage-derived protein soluble CD163 independently predict shorter progression-free survival in metastatic ...
The Amino Acid Arginine Emerges as a Brake on the NLRP3 Inflammasome
A Nature Metabolism commentary highlights new evidence that the amino acid l-arginine can inhibit activation of the NLRP3 inflammasome, raising ...
Three Cell Subclusters Uncovered as Drivers of Pancreatic Cancer Cachexia
University of Oklahoma researchers have identified three adjacent cell subclusters in pancreatic tumors that form a feed-forward network driving cancer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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