Nanogels and micelles tame doxorubicin’s inflammatory side effects in macrophages
Chemotherapy saves lives, but it can also leave chaos in its wake. One of the most widely used anticancer drugs, ...
Tag: macrophages
Mount Sinai Wins $20.7 Million Deal to Build a Next-Generation Respiratory Vaccine Platform
Mount Sinai researchers have received a five-year, $20.7 million agreement to develop the VITAL vaccine platform, beginning with an intranasal ...
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Myeloid IL6/STAT3 Signaling Builds Immunosuppressive Niche That Fuels Colitis-Linked Cancer
Multi-omics study reveals how myeloid-derived IL6/JAK/STAT3 signaling creates a spatially organized immunosuppressive niche that drives colitis-associated carcinogenesis, offering a potential ...
IL-18 Cytokine Drives Inflammatory Senescence and Blocks Skeletal Regeneration
Macrophage-derived IL-18 triggers inflammatory senescence and feed-forward inflammation that suppresses mesenchymal stem cell osteogenesis, impairing skeletal regeneration in mice and ...
Immune Cells Remodel Skin Architecture in Post-Kala-Azar Dermal Leishmaniasis
New research reveals how chemokine-driven immune infiltration and inflammatory enzymes dismantle the skin's structural framework in Post-Kala-Azar Dermal Leishmaniasis, explaining ...
Hypertensive Stress Rewires Immune Cell Signals in a Common Heart Failure Syndrome Independent of Obesity
A new study shows that hypertensive stress rewires cardiac macrophage signaling, impairing metabolic support for heart muscle cells while driving ...
Gut Microbes and Lung Cancer: Genes Point to Six Suggestive Links, But Butyrate Experiments Steal the Show
A Mendelian randomization study of 119 gut microbial genera finds six suggestive inverse associations with non-small cell lung cancer risk, ...
AI-Powered Map of Glioblastoma Reveals Tumor Ecosystem States and Immune Programs
A machine-learning-assisted reanalysis of single-cell and bulk transcriptomic data provides a reproducible framework for characterizing glioblastoma ecosystem states while carefully ...
Radiotherapy Leaves a Lasting Inflammatory Signature in the Saliva of Head and Neck Cancer Patients
A new study finds that radiotherapy persistently raises pro-inflammatory cytokines in the saliva of head and neck cancer patients, mirroring ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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