Macrophages Link Aging and Osteoporosis Through Shared Genetic Pathways
New research identifies macrophages as key mediators linking aging and osteoporosis, revealing a bidirectional causal relationship driven by shared genetic ...
Tag: macrophages
Stem Cell Exosomes From Human Urine Protect Mice Against Sepsis-Induced Kidney Injury
Extracellular vesicles derived from human urine stem cells attenuated renal damage, oxidative stress, and inflammation in a murine model of ...
Enzyme PFKFB4 Drives Macrophage Reprogramming and Liver Tumor Growth via Histone Lactylation
Researchers have revealed that the glycolytic enzyme PFKFB4 accelerates hepatocellular carcinoma growth by stimulating lactate-driven histone lactylation to polarize tumor-associated ...
Maternal-Fetal Immune Atlas Links Conserved Inflammatory Macrophages to Preterm Membrane Rupture
An integrated transcriptomic atlas of the human maternal-fetal interface reveals a conserved inflammatory macrophage program governed by WTAP that is ...
Spatial Genomics Reveals Cardiac Inflammaging Concentrates Around Heart Valves and Aorta
Researchers using single-cell and spatial genomics have mapped cardiac inflammaging in mice, discovering that age-related inflammation and fibrosis concentrate primarily ...
Lipid mediator impairs macrophage immunity against tuberculosis
A new study reveals that the lipid mediator Resolvin D5 reprograms macrophage metabolism via GPR32 signaling, impairing the immune system's ...
Type I Interferon-Induced Viperin Promotes Tuberculosis Survival by Inhibiting Macrophage Defenses
A study reveals that type I interferon-induced viperin enables Mycobacterium tuberculosis survival in macrophages by suppressing the protective COX-2, PGE2, ...
TET2 controls AGO2, linking DNA methylation to RNA regulation in leukaemia
A new study shows that the leukaemia gene TET2 directly controls the RNA-regulating protein AGO2, and reducing AGO2 impaired leukaemia ...
Macrophage-Derived Migrasomes Drive Fibrotic Remodeling in Mouse Endometriosis Model
In a mouse model of endometriosis, macrophage-derived migrasomes reached ectopic lesions and promoted fibrotic remodeling alongside TGF-β/Smad pathway activation.
Plant extract shows antimalarial, anticancer and anti-inflammatory activity in lab tests
A hydroethanolic extract of Erycibe paniculata showed antimalarial, anticancer and anti-inflammatory effects in cell-based laboratory tests with no cytotoxicity observed.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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