Blood-Brain Barrier Leaks Distort Brain Tumor PET Scans, Mouse Study Reveals
A mouse study shows that TSPO-PET signals in glioblastoma remain largely cell-specific early on but lose specificity as blood-brain barrier ...
Tag: macrophages
Fat Thieves: How Leishmania infantum Rewires Host Cell Lipids to Fuel Infection
New lipidomic research reveals how Leishmania infantum systematically drains and remodels host macrophage lipids to build its own biomass and ...
Immune Cell Fat Switch: Losing RORα Worsens Blinding Eye Disease in Mice
A new mouse study shows that the lipid-sensing nuclear receptor RORα restrains PPARγ-driven fat accumulation in retinal immune cells, and ...
Tiny DNA Insert in a Super-Enhancer Fine-Tunes Two Cancer Genes in Breast Tumors
A common germline insertion within a bifunctional super-enhancer dampens the expression of the cancer-promoting genes LINC00636 and CD47 in breast ...
Nanoparticles That Clear Scar-Driving Immune Cells Open Tumors to Immunotherapy
Memorial Sloan Kettering scientists engineered fucoidan-coated nanoparticles that selectively eliminate senescent, P-selectin-positive macrophages driving fibrosis, dissolving scar barriers around tumors ...
Single-Cell Map Reveals Vascular Barrier That Predicts BCG Failure in Bladder Cancer
A stage-spanning single-cell atlas of bladder cancer identifies a CXCR4-positive vascular-immune barrier at the T1 stage that excludes T cells ...
Neutrophil Traps and Inflammatory Macrophages Team Up in Failing Hearts
New human heart tissue analysis reveals that excessive neutrophil NET formation in heart failure is strongly linked to a shift ...
In a Dish, Male and Female Macrophages Wage Inflammation Differently
Researchers coaxed stem cells from male and female donors into macrophages and found that inflammation dramatically widens the genetic and ...
Alzheimer’s Disease Sabotages the Bone Marrow, Starving the Brain of Healing Immune Cells
A new Nature Neuroscience study shows that Alzheimer's disease disrupts bone marrow monocyte production through chronic type I interferon signaling, ...
Common ‘Forever Chemical’ PFNA Found to Ignite Gut Inflammation at Tiny Doses
New research shows that low-dose exposure to the forever chemical PFNA worsens intestinal inflammation by activating a caspase-11-dependent NLRP3 inflammasome ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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