Immune Cells Caught arming the Deadliest Breast Cancer to Spread
New research reveals that inflammatory macrophages fuel metastasis in triple-negative breast cancer by activating a stress-signaling pathway in tumor cells ...
Tag: macrophages
Scientists Map the Hidden Cellular Matrix Landscapes That Drive Allergic Airway Inflammation
A new imaging mass cytometry pipeline reveals region-specific extracellular matrix environments that shape immune cell behaviour during allergic airway inflammation ...
Hidden Protein Bosses the Cleanup Crew That Keeps Lupus at Bay
Scientists have discovered that the protein FAM76B regulates macrophage clearance of dying cells through an m6A-ISG15-autophagy pathway whose failure drives ...
Uterine Monocytes Shown to Play Dual Roles in Tissue Renewal and Reproductive Disease
New research reveals that uterine monocytes replenish macrophage populations that maintain tissue homeostasis across reproductive cycles, with disruptions linked to ...
Gut Bacteria to Lung Damage: Single-Cell Map Reveals How a Traditional Mineral Medicine Turns Toxic
Single-cell transcriptomics, metabolomics, and microbiome sequencing reveal that high-dose Haematitum triggers gut dysbiosis that silences anti-inflammatory macrophage PPAR signaling, unleashes ...
Lung Immune Cells Show Lasting Epigenetic Changes in Long COVID Patients
A Swedish longitudinal study finds that lung immune cells, but not blood cells, undergo lasting DNA methylation changes in long ...
Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize ...
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
How Microbial Adhesion Switches On Piezo1 to Launch Innate Immunity
A new Nature Immunology study shows that microbial adhesion to myeloid cells activates the mechanosensitive ion channel Piezo1, triggering a ...
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
Paired structural snapshots of GPR84 in different conformational states, combined with immune cell assays, reveal how ligands activate, block or ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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