Blocking a Single Kinase May Steer Immune Cells Toward Safer Atherosclerotic Plaques
New research shows that removing protein kinase C delta reprograms macrophage metabolism to suppress inflammatory pyroptotic cell death and stabilize ...
Tag: macrophages
Liver Macrophages Carrying Apolipoprotein E Act as a Molecular Brake That Drives T Cell Exhaustion and Preserves Transplant Tolerance
A specialized APOE-producing Kupffer cell population in transplanted livers restrains rejection by driving attacking CD8-positive tissue-resident memory T cells into ...
How Microbial Adhesion Switches On Piezo1 to Launch Innate Immunity
A new Nature Immunology study shows that microbial adhesion to myeloid cells activates the mechanosensitive ion channel Piezo1, triggering a ...
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
Paired structural snapshots of GPR84 in different conformational states, combined with immune cell assays, reveal how ligands activate, block or ...
Signaling Antagonism Helps Macrophages Identify Threats in Complex Ligand Mixtures
A combination of mathematical modeling and live-cell imaging shows that competition between signaling pathways, rather than hindering immune detection, actually ...
Senescent Kidney Cells Build Inflammatory Niches That Senolytics Can Dissolve
Researchers have mapped how senescent kidney cells attract immune cells into localized inflammatory niches and shown that senolytic treatments can ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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