Subtle Shape Shifts, Not Misfolding: How FUS Mutations Drive ALS
A computational study shows that ALS-linked FUS mutations cause disease through subtle, site-specific changes in protein flexibility and molecular recognition ...
Tag: intrinsically disordered proteins
Lightweight AI Tool Outsmarts Deep Learning at Spotting Disordered Proteins
A researcher at IIIT Allahabad has developed IDP-T5CKNN, a lightweight protein language model method that outperforms more than 20 existing ...
Scientists Receive Up to $51.7 Million to Predict Protein Misfolding Before Disease Begins
A co-led Buck Institute and Georgetown University team has won an ARPA-H award of up to $51.7 million to predict ...
AI Meets Living Cells in $28.6 Million Bid to Predict Protein Misfolding Before Disease Strikes
A Stowers Institute scientist will help lead a $28.6 million ARPA-H effort to generate billions of protein aggregation measurements and ...
Heart Disease Genetics: Little-Known Chaperone Hero11 Emerges as Coronary Risk Gene
Genetic variants in the heat-resistant obscure chaperone protein Hero11, encoded by C19orf53, are associated with coronary artery disease risk and ...
Water Bears’ Survival Secrets Point to Convergent Evolution in Stress Proteins
A multi-species bioinformatics analysis of four tardigrade genomes reveals new Dsup diversity, conserved protein motifs, and statistical signatures of convergent ...
Machine Learning Hunts Down Hidden Gene Switches Across the Fungal Tree of Life
Researchers at UC Berkeley used active learning and a model called ADhunter to discover and characterize nearly 10,000 transcriptional activator ...
Antibiotic Stress Puts Probiotic Bacteria Into Hibernation, Boosting Their Survival
Researchers found that sublethal rifampicin exposure drives Lactobacillus delbrueckii subsp. bulgaricus into a reversible dormant state in which protein aggregates ...
Rational Design of Disordered Proteins Enables Sequence-Function Investigation
Intrinsically disordered proteins (IDRs)—segments that do not adopt a single stable 3D structure—are common across life and perform crucial cellular ...
Designing Relationships in Intrinsically Disordered Proteins
In the realm of protein science, a significant frontier has emerged, focusing on intrinsically disordered proteins (IDPs). Unlike their well-folded ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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