Heat and Itaconate Combine to Rebuild Bone in Diabetes
A dual-function hydrogel that pairs itaconate release with staged photothermal heating restored bone healing in infected diabetic defects in rats ...
Tag: HSP90
Research report: Progress in the Mechanism of Heat Shock Proteins in Gastric Cancer: From Biomarkers to Therapeutic Targets
A narrative review links heat shock proteins to gastric cancer invasiveness, resistance and immune modulation, but finds that most therapeutic ...
Malaria Parasite’s Odd Hsp90 Chaperone Proves Druggable in Yeast Screen
Researchers have shown that the malaria parasite's divergent second Hsp90 chaperone is functional, essential and selectively inhibited by the compound ...
Tumor Protein CEMIP Hijacks Immune Cells to Fuel Colorectal Cancer Drug Resistance
New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...
Omics Sweep of Cat Parasite Surfaces Repurposing Targets for a Drug-Resistant Disease
An integrative omics study of Tritrichomonas foetus has identified hundreds of drug-target candidates, most of which belong to protein families ...
Chaperone Blockade Turns a Hidden Stress Protein Into a Target for CAR Immunotherapy
New research shows that blocking the HSP90 chaperone forces stressed tumor cells to display GRP78 on their surface, making drug-resistant ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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