Yeast Cell Model Shows Cell Geometry Reshapes Gene Network Predictions
A spatially resolved model of the yeast galactose switch shows that intracellular architecture, especially ER-bound translation, changes gene regulation predictions.
Tag: Gene regulation
Why Some Neurons Survive: Identity Maintenance May Set the Threshold of Neurodegeneration
A new PLOS Biology essay proposes that a neuron's capacity to maintain its subtype-defining gene-regulatory machinery may set the stress ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
Ancient DNA Reorganization May Explain How Octopuses Grew Such Complex Brains
A University of Vienna study finds that an ancient burst of genome reorganization created 3D DNA interactions, or regulatory entanglement, ...
One Master Switch: How a Soil Bacterium Coordinates Warfare and Microbiome Reshaping
A new study reveals that the regulatory protein GacS acts as a master switch in Pseudomonas fluorescens, coordinating antibiotic production ...
One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
CRISPR Screen Maps the Hidden Control Network of the Body’s Pollution-Sensing Receptor
A genome-scale CRISPR screen in human hepatocytes has revealed an extensive network of regulators governing the aryl hydrocarbon receptor, including ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Computational Microscope Opens a New Window on Chromatin Folding
An international team has developed OpenCGChromatin, an open-source simulation tool that acts as a computational microscope to reveal how chromatin ...
Aging May Stem From a Genome-Wide Shift That Sidelined Cellular Maintenance
A new GeroScience study finds that after sexual maturity, housekeeping genes lose transcriptional share to specialized integrative genes across species, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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