AI and Omics Converge to Decode the Gene Regulatory Logic of the Brain
A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...
Tag: Gene regulation
New ensemble tool sharpens chromatin interaction calls in 4C-seq data
A weighted-voting ensemble called fourSynergy outperformed individual 4C-seq algorithms in leave-one-group-out cross-validation, reaching a mean F1-score of 0.31 and mean ...
Viral RNA contacts leave immune gene promoters accessible yet transcriptionally constrained
A computational reanalysis of public EBV data finds that promoters contacted by the viral EBER noncoding RNAs remain chromatin-accessible yet ...
SIX1 and TEAD1 Team Up to Drive Colorectal Tumor Growth via CTGF
A new study shows the transcription factors SIX1 and TEAD1 synergistically promote colorectal tumor growth by directly co-regulating the CTGF ...
VrMYB80 Shapes Pollen Development in Mungbean by Activating VrLBD27 and VrWBC27
A genome-wide DAP-seq study in mungbean identifies VrWBC27 and VrLBD27 as likely direct transcriptional targets of the VrMYB80 regulator of ...
G-quadruplex motifs cluster near gene starts across oral bacterial genomes
A computational survey of 381 oral bacterial genomes found 48,234 G-quadruplex motifs, with a 2.5 to 3-fold enrichment in promoter ...
Switchgrass gene PvHIPP23 acts as a brake on cadmium tolerance
A genome-wide study of switchgrass identified 79 HIPP genes and found that silencing PvHIPP23 improves cadmium tolerance while reducing root ...
Scientists discover a conserved mitochondrial RNA shared by zebrafish and humans
A newly identified mitochondrial long noncoding RNA, lncOriL, found in zebrafish and conserved in humans, may reveal an unrecognized layer ...
Single-nucleus maps of human skeletal muscle expose cell-specific genetic control of metabolic traits
A population-scale single-nucleus study of 287 human skeletal muscle biopsies maps cell-type-specific eQTLs and caQTLs that colocalize with thousands of ...
Alx4 keeps its limb-building role even as its expression shifts across amniotes
A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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