Hidden RNA Switch Drives Airway Remodeling Through a Metabolic FUS/HK2 Axis
A new study reveals that the lncRNA HOTAIR drives airway smooth muscle remodeling by stabilizing HK2 mRNA through the RNA-binding ...
Tag: FUS
Subtle Shape Shifts, Not Misfolding: How FUS Mutations Drive ALS
A computational study shows that ALS-linked FUS mutations cause disease through subtle, site-specific changes in protein flexibility and molecular recognition ...
Silencing SLITRK2 Rescues Damaged Nerve-Muscle Connections in FUS-ALS Motor Neurons
Researchers found that reducing SLITRK2 levels in human stem cell-derived FUS-ALS motor neurons restores axonal health and neuromuscular junction signaling, ...
Rare Sarcomas With Shared Genes Follow Two Very Different Paths, Study Finds
A Portuguese reference-centre study of twenty patients shows that low-grade fibromyxoid sarcoma and sclerosing epithelioid fibrosarcoma, though molecularly related, follow ...
How Molecular Flux and Rigid β Motifs Drive Fibril Growth at Condensate Interfaces
New simulations reveal that rigid β-prone motifs and the rate of molecular delivery jointly determine whether aging condensate interfaces spread ...
Molecular Chaperones Keep ALS Protein Droplets From Hardening Into Disease
A new review in BMC Medicine argues that ALS arises when the cellular systems that keep reversible protein condensates from ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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