RNA 5-methylcytosine cancer biomarkers face a measurement gap, not a biology gap
A new review argues that the slow clinical translation of RNA 5-methylcytosine cancer biomarkers stems from a lack of analytically ...
Tag: epitranscriptomics
RNA acetylation enzyme NAT10 drives aortic valve calcification through PCSK9
A new iScience study shows that the RNA acetyltransferase NAT10 stabilizes PCSK9 mRNA through N4-acetylcytidine modification, driving the osteogenic transformation ...
Ribosomal RNA Tag and a Detox Enzyme Form a Deadly Cancer Survival Circuit
A new review describes how the RNA methyltransferase METTL5 and the detox enzyme MGST1 form a signaling axis that helps ...
Two Molecular Machines, One Cancer Engine: How Deubiquitinases and m6A RNA Tags Talk to Each Other
A new review in Molecular Cancer maps the bidirectional crosstalk between deubiquitinases and m6A RNA modification, revealing a coupled regulatory ...
RNA edit swaps out OCT4 to make better stem cells
Researchers discovered that the RNA-modifying enzyme PUS7 pseudouridylates the noncoding RNA 7SK to recruit the BAF chromatin-remodeling complex, enabling a ...
RNA Cap Modification Emerges as a Switch That Governs Tumor Response to Radiotherapy
A new study shows that the RNA cap-modifying enzyme PCIF1 drives tumor growth and radioresistance, and that removing its m6Am ...
Leishmania Parasites Rewire Their Genes to Survive Antimony Drug Attacks
New research reveals that Leishmania parasites survive antimony treatment through active transcriptome remodeling, a transient persister state that may pave ...
Chemical Tag on RNA Helps Melanoma Dodge Ferroptosis, Study Finds
New research shows that the m6A reader protein YTHDF2 promotes melanoma progression by destabilizing HMOX1 mRNA and shielding tumor cells ...
Super Elongation Complex Found to Switch On Genes That Transform Cell Identity
New research shows that the Super Elongation Complex drives both stem cell reprogramming and neural differentiation by releasing paused RNA ...
Fly Study Reveals How the RNA Modifier Mettl16 Shapes Development and Fertility
New research in fruit flies shows that the RNA methyltransferase Mettl16 is dispensable for survival but essential for fertility, acting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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