CRISPR Methylation Sensing Moves Toward Next-Generation Epigenetic Diagnostics
A new review details how CRISPR-Cas enzymes can be engineered to detect DNA and RNA methylation with single-nucleotide precision, charting ...
Tag: epitranscriptomics
Chemical Tags on Messenger RNA Steer the Plasticity of Pancreatic Alpha Cells
A new Nature Metabolism study shows that m6A methylation of messenger RNA actively controls the plasticity of pancreatic alpha cells, ...
Chemical Tags on mRNA Keep Pancreatic Alpha Cells From Turning Into Beta-Like Cells
New research shows that the mRNA modification m6A, installed by METTL14, is required to maintain pancreatic alpha-cell identity and prevent ...
TET2 Emerges as Genetic Switch Driving Inflammatory Monocytes in Asthma
A new study identifies TET2 as an m6A-regulated gene that drives inflammatory monocyte activation in asthma through ALKBH5-mediated RNA demethylation ...
Hidden RNA Tag Drives Paclitaxel Resistance in Bladder Cancer, Study Finds
Researchers report that the RNA-binding protein IGF2BP3 stabilizes m6A-tagged CENPA mRNA to fuel paclitaxel resistance in bladder urothelial carcinoma, identifying ...
Lactate Signals and RNA Tags May Shape Post-Hemorrhage Depression, Review Proposes
A new review proposes that histone lactylation and m6A RNA methylation may link acute brain hemorrhage to long-term depression, anxiety, ...
METTL3 Emerges as a Molecular Hub Driving Tumor Immune Escape
A new review in the Journal of Translational Medicine details how the RNA methyltransferase METTL3 drives tumor immune escape through ...
RNA Acetylation Enzyme NAT10 Helps Glioblastoma Resist Radiotherapy
Researchers found that the RNA acetyltransferase NAT10 helps glioblastoma resist radiotherapy by stabilizing SLC7A11 mRNA and blocking immunogenic ferroptosis, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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