RNA Methylation Enzyme METTL16 Emerges as Guardian of Rod Photoreceptor Survival
New research shows that the RNA methyltransferase METTL16 protects rod photoreceptors by safeguarding splicing fidelity, mRNA stability, and translation, and ...
Tag: epitranscriptomics
RNA Tag METTL3 Drives Lung Scarring by Destabilizing a Key Fat-Droplet Protein
New research shows that the RNA methyltransferase METTL3 promotes lipid deposition and pulmonary fibrosis by destabilizing the messenger RNA of ...
Chemical Tags on RNA Drive Cancer Spread and Treatment Failure, Review Finds
A comprehensive review in Molecular Cancer details how chemical modifications to RNA molecules regulate tumor metastasis and therapy resistance, opening ...
Chemical Tags on RNA Take Center Stage in Cancer’s Growth and Immune Evasion
A new review in Molecular Cancer details how the abundant RNA mark m6A drives cancer growth, immune evasion and treatment ...
CRISPR Methylation Sensing Moves Toward Next-Generation Epigenetic Diagnostics
A new review details how CRISPR-Cas enzymes can be engineered to detect DNA and RNA methylation with single-nucleotide precision, charting ...
Chemical Tags on Messenger RNA Steer the Plasticity of Pancreatic Alpha Cells
A new Nature Metabolism study shows that m6A methylation of messenger RNA actively controls the plasticity of pancreatic alpha cells, ...
Chemical Tags on mRNA Keep Pancreatic Alpha Cells From Turning Into Beta-Like Cells
New research shows that the mRNA modification m6A, installed by METTL14, is required to maintain pancreatic alpha-cell identity and prevent ...
TET2 Emerges as Genetic Switch Driving Inflammatory Monocytes in Asthma
A new study identifies TET2 as an m6A-regulated gene that drives inflammatory monocyte activation in asthma through ALKBH5-mediated RNA demethylation ...
Hidden RNA Tag Drives Paclitaxel Resistance in Bladder Cancer, Study Finds
Researchers report that the RNA-binding protein IGF2BP3 stabilizes m6A-tagged CENPA mRNA to fuel paclitaxel resistance in bladder urothelial carcinoma, identifying ...
Lactate Signals and RNA Tags May Shape Post-Hemorrhage Depression, Review Proposes
A new review proposes that histone lactylation and m6A RNA methylation may link acute brain hemorrhage to long-term depression, anxiety, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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