Female X chromosomes show lower methylation than male X in human brain
A chromosome-wide analysis of 89 human brain methylomes finds that the combined methylation of female X chromosomes is globally lower ...
Tag: epigenetics
Long-read sequencing maps the hidden 5hmC landscape of human neurons
Using native long-read nanopore sequencing, researchers have simultaneously mapped 5mC and 5hmC across the whole genome of human neuronal nuclei, ...
HAT1 Emerges as a Driver of Glioblastoma Growth and Drug Sensitivity
A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...
DNA Methylation of Two Long Non-Coding RNA Loci Tracks Metastatic Disease in Kidney Cancer
DNA methylation at the LINC01354 and LINC01510 long non-coding RNA loci rises with tumor stage, grade and metastatic spread in ...
Macrophages engineered to donate mitochondria restore nerve repair in rat erectile dysfunction model
Engineered macrophages that transfer mitochondria to Schwann cells restored erectile function in a rat model of cavernous nerve injury by ...
NAT10 enzyme adds ketone-derived tag to histones to speed DNA replication
A new study reports that the enzyme NAT10 catalyzes histone β-hydroxybutyrylation, a modification that accelerates replication fork speed and reduces ...
Epigenetic switch drives ERK signaling in glioblastoma, study finds
A study identifies an SP1/P300/TRAF3IP3 signaling axis that links promoter-specific chromatin remodeling to persistent ERK activation in glioblastoma.
Urine may reveal aging-related DNA demethylation changes better than leukocytes
A study of healthy volunteers aged 1.5 to 71 found that urinary levels of active DNA demethylation products decline with ...
Plant waste enzymes and nanozymes team up to break down pesticides
A new review proposes combining enzymes fermented from agricultural waste with artificial nanozymes to degrade persistent pesticides such as chlorpyrifos ...
Mitochondrial Damage May Drive Varicocele Infertility Through Oxidative Stress and Sterile Inflammation
A narrative review proposes that mitochondrial injury links varicocele-related oxidative stress and sterile inflammation, while stressing that the full pathway ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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