CREBBP mutation drives lymphoma growth and T-cell exhaustion via NOTCH pathway
A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell dysfunction ...
Tag: epigenetics
Blocking a Methylation Enzyme Keeps Sperm Stem Cells Young Across Species
Researchers report that inhibiting the methyltransferase PRMT5 with EPZ015666 keeps mouse, monkey and human spermatogonia proliferating in an undifferentiated state ...
Vitamin B12 Intake Linked to Lower Insulin Resistance Through Epigenetic Changes
A six-year epigenome-wide association study in older adults without type 2 diabetes found that higher vitamin B12 intake was associated ...
Epigenetic ‘metabolic memory’ may keep injuring the diabetic heart after blood sugar improves
A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...
Monocytes in rheumatoid and psoriatic arthritis follow distinct inflammatory paths
A new study finds that CD14-positive monocytes from rheumatoid arthritis and psoriatic arthritis patients show distinct inflammatory, metabolic, epigenetic and ...
PCOS reframed as PMOS: fetal programming, epigenetics and puberty’s second hit
A new review proposes that polyendocrine metabolic ovarian syndrome arises from prenatal epigenetic programming that is unmasked by puberty and ...
Azacitidine and DNMT3A emerge as candidate targets in osteoarthritis synovium
A bioinformatic drug-repurposing study points to the epigenetic regulator DNMT3A in synovial cells as a candidate driver of osteoarthritis inflammation, ...
Astragaloside IV Eases Fatty Liver by Epigenetically Silencing a Lipogenesis Switch
A new preclinical study reports that the Astragalus compound astragaloside IV reduces hepatic fat accumulation in mice and human liver ...
DNA Methylation Score Sharpens Leukemia Risk Prediction in MDS
A 55-CpG DNA methylation signature developed from bone marrow samples and validated in an independent cohort appears to predict AML ...
Metformin and valproic acid combo strips cancer cells of chemo tolerance
A combination of low-dose metformin and valproic acid reprograms the metabolism of drug-tolerant persister cells in gastric and liver cancer ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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