Fungus study reveals how a histone mark switches on a key antioxidant enzyme
Researchers report that loss of the SET-1-mediated H3K4me3 histone mark in Neurospora crassa lowers catalase-3 expression and increases hydrogen peroxide ...
Tag: epigenetics
RNA-binding protein MSI1 keeps stem cells pluripotent by steering iron to DNA demethylation machinery
A new study shows that the RNA-binding protein MSI1 stabilizes the ferritin-like transcript Fthl17c, preserving the ferrous iron supply that ...
Ancestral genistein diet shifts quail body weight across three generations
Japanese quails whose founding mothers ingested genistein grew progressively heavier than genetically matched controls over three generations, with the epiline's ...
Loss of FTO demethylase drives hepatic stellate cell activation in mouse fibrosis model
A new Scientific Reports study links loss of the m6A demethylase FTO to hepatic stellate cell activation and liver fibrosis ...
Loss of Epigenetic Regulator ASH2L Causes Cleft Palate in Mice
Deleting the epigenetic regulator Ash2l from developing palatal mesenchyme collapses the H3K4me3 histone mark, silences Wnt5b, and produces complete cleft ...
Three sequencing methods tested on archival breast tumor DNA methylation
Researchers showed that whole-genome bisulfite sequencing, EM-seq, and the biomodal evoC kit are all feasible for DNA methylation profiling of ...
Polycomb Protein PCGF1 Steers Astrocyte Development by Guarding Notch Signals
Deleting the Polycomb protein PCGF1 in the mouse dorsal forebrain selectively blocks astrocyte production by lifting repression of N4bp1, a ...
Hypoxia Silences an Invasion-Braking Gene in Oral Cancer via a Nuclear LOX-H1.5 Pathway
Researchers report that hypoxia activates a nuclear LOX-H1.5 decrotonylation axis that represses the DAG1 gene and promotes invasive progression in ...
Epigenetic Split in AKAP12-LMOD1 Axis Shapes Colorectal Cancer Stroma and Epithelium
A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...
Enzyme Rivalry in Tumors: How Arginine Methyltransferases Cooperate and Compete in Cancer
A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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