Histone Lactylation Drives ALKBH5 to Worsen Cardiac Hypertrophy via ATF6 Demethylation
A study in Cell Biology and Toxicology reports that H3K18 lactylation promotes ALKBH5 transcription, which stabilises ATF6 mRNA through m6A ...
Tag: epigenetics
BRCA1/2 Mutation Carriers Show Fewer Active Ribosomal DNA Copies in Blood
Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...
Gene Screens in Aged Mice Reveal Two Distinct Routes to Restore Tumor-Fighting T Cells
Genetic screens in aged mice identify Dusp5 and Zfp219 as regulators whose deletion can restore anti-tumor T cell function, with ...
EBV-driven lymphoproliferative disorders show disrupted DNA methylation patterns
A new review links EBV-driven lymphoproliferative disorders to disrupted DNA methylation and outlines emerging epigenetic treatment strategies.
Rumpelstiltskin Protein Guards Genome Boundaries in Fruit Flies
A new study finds that the Drosophila protein Rumpelstiltskin maintains the Homie insulator barrier and shapes Polycomb domain interactions in ...
Omega-3 Fatty Acids Linked to Better Lung Health in Smokers Through Epigenetic Recovery
A large observational study of former and current smokers found that higher blood omega-3 fatty acids were associated with better ...
Mitochondrial DNA methylation signals in WGBS are mostly technical artifacts
A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, ...
DNA Methylation Links Failing Fat Cell Formation to Obesity and Diabetes
A new review describes how aberrant DNA methylation and premature senescence of fat cell precursors drive adipose tissue dysfunction in ...
How metabolism may reshape DNA methylation across the cardiovascular–kidney–metabolic continuum
A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes ...
Maternal Diabetes Linked to Cranial Neural Tube Defects via Elevated H3K18cr
A mouse study links maternal diabetes-induced cranial neural tube defects to elevated H3K18 crotonylation and silencing of AKT and PIKFYVE.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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