First Mosaic Case Rewrites the Genetic Story of a Rare Overgrowth Syndrome
Researchers report the first known case of Cohen–Gibson syndrome caused by a mosaic EED variant, expanding the mutational spectrum of ...
Tag: epigenetics
Hidden DNA Rings and a Rogue Gene Reveal Ovarian Cancer’s Adaptive Defense
A new study links HDAC inhibitor treatment to remodeling of extrachromosomal circular DNA in ovarian cancer and identifies LMO2 as ...
Cancer Cells Rewire Immune Neutrophils Through a Fumarate-Driven Metabolic Switch, Study Finds
A new Nature Cancer study reveals that the kinase GSK3β in colorectal tumor cells drives fumarate accumulation that epigenetically reprograms ...
Crushing Rice Seeds Under Pressure Leaves Genetic Scars That Last Nine Generations
A rice lineage derived from seeds treated with 100 megapascals of hydrostatic pressure still shows reduced height, tiller number, and ...
Loss of Tet2 Rewires the Aging Bone Marrow to Drive Blood Cancers, Mouse Study Shows
A new conditional knockout mouse model shows that loss of the epigenetic regulator Tet2, combined with aging and a reshaped ...
Lactate Tag on Histones Fuels Drug Resistance in Head and Neck Cancer
New research shows that CBP-driven histone H3K18 lactylation activates GLI2 transcription, promoting head and neck squamous cell carcinoma progression and ...
PCOS Gets a New Name and a Radical New Explanation
A major review argues that the newly renamed polyendocrine metabolic ovarian syndrome is a lifelong systems-level disease driven by hypothalamic, ...
Fish Liver DNA Methylation Reveals Hidden Switches Controlling Egg Development
A new whole-genome bisulfite sequencing study shows that DNA methylation changes in the spotted scat liver are linked to the ...
Lactate’s Hidden Switch: How a Once-Dismissed Metabolite Shapes Brain Repair and Degeneration
A new review in the Journal of Translational Medicine details how lactate and protein lactylation act as a double-edged sword, ...
Quitting Smoking May Rewind Your Biological Clock, Epigenetic Study Suggests
A study of nearly 2,000 US adults found that epigenetic age acceleration from smoking declines steadily after cessation, with former ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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