Exercise metabolites act as messengers that reprogram gene activity during muscle repair
A new review proposes that exercise-generated metabolites such as lactate, acetyl-CoA, NAD+ and SAM directly regulate epigenetic enzymes that steer ...
Tag: epigenetics
Epigenetic memory or metabolic reprogramming? A new framework sorts the evidence in cardiovascular disease
A review in Clinical Epigenetics applies eight criteria to 43 evidence units to separate true metaboloepigenetic memory from reprogramming under ...
Cell division resets epigenetic marks to keep plant stem cells ready for branching
Active cell-cycle progression periodically resets repressive H3K27me3 marks in Arabidopsis bud precursor cells, keeping the meristem gene STM expressed, while ...
EZH2 and E2F1 Upregulation with NF2 Alterations Drives Aggressive Meningiomas
A study of meningioma tumor samples and cell lines links NF2 alterations with upregulated EZH2 and E2F1 pathways to aggressive ...
Single-cell chromatin maps reveal how bone cells open and close their genes
A review in the Journal of Advanced Research synthesizes how single-cell chromatin accessibility studies are reshaping understanding of bone development, ...
Chemotherapy-Induced Senescence in Breast Cancer Cells Is Driven by Histone Lactylation
A multi-omics study shows that lactate produced by senescent breast cancer cells drives the SASP through histone H3 lactylation at ...
Histone Marks May Hold Alzheimer’s Inflammation in a Persistent State
A new review proposes that histone post-translational modifications sustain neuroinflammation in Alzheimer's disease by encoding pathological immune memory in chromatin.
Light acts as a master switch in early plant growth, from cyanobacteria to seedlings
A new Frontiers in Plant Physiology editorial gathers five studies showing how light signals, photoreceptors and maternal light environments steer ...
Cancer’s shape-shifting proteins may explain why drugs stop working
A new review proposes that the constantly shifting shapes of proteins, not just genetic mutations, drive rapid and reversible drug ...
m6A RNA modification emerges as a key sculptor of the tumor microenvironment
A new open-access review describes how the m6A RNA modification acts as a key determinant in reshaping the tumor microenvironment ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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