Mutant KMT2D Rewrites Chromatin and Immune Signals to Drive Follicular Lymphoma
A new study shows that loss-of-function mutations in the chromatin regulator KMT2D promote follicular lymphoma by lowering H3K9me3 marks, activating ...
Tag: epigenetics
Gut Microbes Send Chemical Signals That Shape Cancer and Metabolic Disease
A new review details how microbiome-derived metabolites such as short-chain fatty acids, secondary bile acids, and tryptophan derivatives regulate host ...
EZH2 Blockade Restores Glioblastoma Sensitivity to Radiotherapy in Preclinical Models
A new study reports that irradiation stabilizes EZH2 in glioblastoma, driving H3K27me3-mediated DEPTOR repression and mTOR activation, and that EZH2 ...
How Histone Tweaks Help Deadly Fungi Evade Drugs and Hosts
A new review in Current Genetics details how histone methylation, acetylation, and demethylation regulate virulence, stress responses, and drug resistance ...
Chemotherapy’s hidden toll on sperm DNA comes under review
A new review examines how chemotherapeutic agents damage sperm DNA and germ cells, and what fertility preservation options exist for ...
DNA Methylation Test Matches Flow Cytometry for Measuring Immune Cells in Blood
A new study reports that quantifying immune cells from DNA methylation patterns matches clinical flow cytometry and CBC results within ...
SWI/SNF Chromatin Complex Gene Expression Mapped Across 33 Cancer Types
A pan-cancer analysis of about 11,000 TCGA samples maps the expression of all 29 SWI/SNF chromatin remodeling genes across 33 ...
Asian-led epigenome study uncovers new DNA methylation markers of artery wall thickness
An EWAS in a Singapore-based Asian cohort identified three novel DNA methylation markers for carotid intima-media thickness and linked one ...
DNA hydroxymethylation shifts in the striatum tracked across stages in a Parkinson’s mouse model
In a 6-OHDA mouse model of Parkinson's disease, striatal 5hmC levels and linked synaptic gene programs changed dynamically at two ...
MALAT1 Emerges as Central Driver of Leukemia Cell Survival and Drug Resistance
A new review describes how the long non-coding RNA MALAT1 drives leukemia cell survival, proliferation and chemotherapy resistance in acute ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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