AI Tumor Classifier Proves Its Worth in 516 Tough Brain Cancer Cases
A large evaluation of the Bethesda v3 DNA methylation classifier shows robust performance in routine brain tumor diagnostics, correctly classifying ...
Tag: epigenetics
Why aging immune systems turn against the body: a two-step model of B cell autoreactivity
A new GeroScience review proposes that B cell-intrinsic aging relaxes immune tolerance while chronic inflammaging selectively expands autoreactive B cell ...
Bacterial Inoculation Rewrites the Coral Epigenome, Study Reveals
A new Nature Communications study shows that inoculating corals with beneficial bacteria produces measurable changes in the coral host's epigenome, ...
CRISPR Methylation Sensing Moves Toward Next-Generation Epigenetic Diagnostics
A new review details how CRISPR-Cas enzymes can be engineered to detect DNA and RNA methylation with single-nucleotide precision, charting ...
Decades-Old Newborn Blood Spots Yield High-Quality DNA Methylation Data With Tiny DNA Inputs
A pilot study shows the Illumina MethylationEPIC v2.0 array produces high-quality DNA methylation data from decades-old Swedish newborn blood spots ...
CRISPR Screens Reveal DNMT3A’s Dual Role in Tumor Immune Evasion
In vivo CRISPR screens reveal that the epigenetic enzyme DNMT3A can both preserve and suppress tumor immune visibility, reshaping how ...
Mitochondrial Citrate Transporter SLC25A1 Drives Skin Cancer Through Histone Acetylation
Researchers in China have shown that the mitochondrial citrate transporter SLC25A1 promotes cutaneous squamous cell carcinoma by boosting histone H3 ...
Cryo-EM Reveals How Polycomb Repressive Complex 1 Assembles, Works and Finds Its Targets
Ciapponi and colleagues have determined the cryo-EM structure of the canonical PRC1 holocomplex, revealing how its architecture coordinates assembly, H2A ...
Proteasome Gatekeeper RPT2a Controls When Plants Flower by Destroying a Key Histone Protein
New research reveals that the proteasome subunit RPT2a regulates flowering time in Arabidopsis by promoting the degradation of the chromatin ...
Hidden Enzyme KMT9 Helps Prostate Tumors Evade Immune Attack
New research reveals that the epigenetic enzyme KMT9 orchestrates immune evasion in prostate cancer by recruiting suppressive myeloid cells and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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