Precision Warheads: How Antibody–Drug Conjugates Are Redefining Lung Cancer Treatment
A comprehensive review details how antibody–drug conjugates targeting TROP2, HER2, c-MET, and other antigens are transforming non-small cell lung cancer ...
Tag: drug resistance
Cancer Gene Duo Reveals Why Head and Neck Tumors Shrug Off Cisplatin
New research links the SERPINE1–CA9 gene axis to both aggressive growth and cisplatin resistance in head and neck squamous cell ...
AI, CRISPR and Multi-Omics Converge to Reshape Antileishmanial Drug Discovery
A new review outlines how multi-omics, CRISPR functional genomics, artificial intelligence and host-directed immunotherapy can be integrated into a precision ...
New AI Framework Predicts How Single Cells Choose Their Fates
A new physics-in neural network framework called GRNvelo unifies gene regulatory network dynamics with cell population behavior, accurately reconstructing cell ...
Epigenetic enzyme SMYD3 emerges as Achilles heel of gastric cancer DNA repair
New research reveals that the chromatin-modifying enzyme SMYD3 orchestrates DNA double-strand break repair in gastric cancer, and that blocking it ...
Rare ALK Fusion Lung Cancer Shows Durable Response to First-Line Lorlatinib
A newly reported case shows that first-line lorlatinib achieved durable systemic and intracranial disease control in a patient with the ...
Malaria Parasite Membrane Enzymes Emerge as Promising New Drug Targets
A new review highlights how Plasmodium rhomboid proteases, essential intramembrane enzymes governing parasite invasion and survival, are emerging as validated ...
Scientists Crack the Code of Pyrotinib Resistance in HER2-Positive Breast Cancer
Researchers identified an ASCL1–WNT11–ERK feed-forward loop that sustains pyrotinib resistance in HER2-positive breast cancer and designed a HER2-targeted nanoparticle that ...
How Aging Cells Secretly Help Tumors Grow—and How Scientists Hope to Stop Them
A new review in Cancer Reports details how the senescence-associated secretory phenotype can both suppress and fuel tumors, and how ...
HIV Treatment Exposure Drives Sharp Rise in Multi-Class Drug Resistance
A province-wide study in Jiangxi, China, found that exposure to antiretroviral therapy nearly tripled the prevalence of multidrug resistance among ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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